156358-32-6Relevant academic research and scientific papers
Preparation and ring-opening reactions of N-diphenylphosphinyl aziridines
Cantrill, Alex A.,Osborn, Helen M. I.,Sweeney, Joseph
, p. 2181 - 2208 (2007/10/03)
Monochiral N-Diphenyphosphinyl aziridines ('N-Dpp azinidines') may efficiently be prepared from monochiral 2-aminoalcohols. Such aziridines undergo ring-opening reaction with a variety of nucleophiles in good yield. Dephosphinylation is accomplished under mild conditions.
Synthesis of enantiopure N-and C-protected homo-β-amino acids by direct homologation of α-amino acids
Caputo, Romualdo,Cassano, Ersilia,Longobardo, Luigi,Palumbo, Giovanni
, p. 12337 - 12350 (2007/10/02)
Enantiopure N-and/or C-protected homo-β-amino acids are prepared readily and in good yields from N-protected α-amino acids with the same side chain, via reduction of the carboxyl function and conversion of the resulting N-protected β-amino alcohol into the corresponding β-amino iodide and then β-amino cyanide. The key step of this strategy is represented by the synthesis of the enantiopure N-protected β-amino iodides 2 and 3 that are smoothly obtained from the parent amino alcohols 1 by polymer bound triarylphosphine-I2 complex in anhydrous dichloromethane.
