154669-56-4

Basic information

• Product Name: (S)-N-Boc-α-(iodomethyl)benzeneethanamine
• Synonyms: (S)-N-Boc-α-(iodomethyl)benzeneethanamine;(R)-N-Boc-α-(iodomethyl)benzeneethanamine;N-[(1S)-1-(IodoMethyl)-2-phenylethyl]carbaMic Acid 1,1-DiMethylethyl Ester
• CAS NO: 154669-56-4
• Molecular Formula: C₁₄H₂₀INO₂
• Molecular Weight: 361.21857
• Product Categories: Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 154669-56-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 121-122 °C
• Boiling Point: 405.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.428±0.06 g/cm3(Predicted)
• PKA: 11.81±0.46(Predicted)
• CAS DataBase Reference: (S)-N-Boc-α-(iodomethyl)benzeneethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-Boc-α-(iodomethyl)benzeneethanamine(154669-56-4)
• EPA Substance Registry System: (S)-N-Boc-α-(iodomethyl)benzeneethanamine(154669-56-4)

Safety Data

• Hazardous Substances Data: 154669-56-4(Hazardous Substances Data)

Usage

Description

(S)-N-Boc-α-(iodomethyl)benzeneethanamine is an organic compound that serves as an intermediate in the synthesis of various pharmaceuticals. It is a white solid with specific chemical properties that make it suitable for use in the production of certain amphetamine derivatives.

Uses

Used in Pharmaceutical Industry:
(S)-N-Boc-α-(iodomethyl)benzeneethanamine is used as an intermediate in the synthesis of (R)-Amphetamine and (S)-Amphetamine for their respective applications in medicine. These amphetamine derivatives are known for their stimulant properties and are used in the treatment of various medical conditions, such as attention deficit hyperactivity disorder (ADHD) and narcolepsy.
Additionally, due to its chemical properties, (S)-N-Boc-α-(iodomethyl)benzeneethanamine may also be utilized in other chemical reactions and processes within the pharmaceutical industry, contributing to the development of new drugs and therapies.

Upstream product

• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 141403-49-8 (2S)-2-[N-(tert-butoxycarbonyl)amino]-3-phenyl-O-(4-methylphenylsulfonyl)propan-1-ol 
• 3182-95-4 L-Phenylalaninol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 63-91-2 L-phenylalanine 

Downstream Products

• 354988-08-2 (5R)-5-[N-(tert-butoxycarbonyl)amino]-6-phenylhexa-1,2-diene 
• 876297-30-2 (2R)-3-[(2'S)-2'-(tert-butyloxycarbonyl)amino-3'-phenylpropylthio]-2-[(fluorenylmethoxycarbonyl)amino]propanoic acid 
• 1172596-81-4 tert-butyl (S)-1-isothiocyanato-3-phenylpropan-2-ylcarbamate 
• 134557-74-7 tert-butyl [(2S)-1-azido-3-phenylpropan-2-yl]carbamate 
• 923279-01-0 di((2S)-2-(t-butoxycarbonylamino)-3-phenylpropyl) diselenide 
• 1315563-37-1 C₂₀H₂₄BrNO₃S 
• 1421788-74-0 (R_S, 2S)-N-Boc-1-((E)-3,3-dimethyl-1-butenylsulfinyl)-3-phenylpropan-2-amine 
• 1421788-75-1 C₂₀H₃₁NO₃S 
• 1421788-72-8 (R_S, 2S)-N-Boc-1-(cyclohexenylsulfinyl)-3-phenylpropan-2-amine 
• 1421788-73-9 C₂₀H₂₉NO₃S 
• 1421788-70-6 (R_S,2S)-N-Boc-1-phenyl-3-(vinylsulfinyl)propan-2-amine 
• 1421788-71-7 C₁₆H₂₃NO₃S 
• 1421788-68-2 (R_S, 2S)-N-Boc-1-phenyl-3-((E)-4-phenyl-1-butenylsulfinyl)propan-2-amine 

Relevant articles and documents

PHENETHYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS WITH AN N-1 BRANCHED GROUP

Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed.

Hydrodehalogenation of alkyl iodides with base-mediated hydrogenation and catalytic transfer hydrogenation: Application to the asymmetric synthesis of N-protected α-methylamines

We report a very mild synthesis of N-protected α-methylamines from the corresponding amino acids. Carboxyl groups of amino acids are reduced to iodomethyl groups via hydroxymethyl intermediates. Reductive deiodination to methyl groups is achieved by hydrogenation or catalytic transfer hydrogenation under alkaline conditions. Basic hydrodehalogenation is selective for the iodomethyl group over hydrogenolysis-labile protecting groups, such as benzyloxycarbonyl, benzyl ester, benzyl ether, and 9-fluorenyloxymethyl, thus allowing the conversion of virtually any protected amino acid into the corresponding N-protected α-methylamine.

PROP-2-YN-1-AMINE INHIBITORS OF MONOAMINE OXIDASE TYPE B

The present invention relates to new prop-2-yn-1-amine inhibitors of monoamine oxidase type B activity, pharmaceutical compositions thereof, and methods of use thereof.