156359-33-0Relevant academic research and scientific papers
Reaction of Normal and Pseudo 2-Formylbenzenesulfonyl Chlorides with Amines: Experimental and Theoretical Studies on the Structure of 2-Formyl benzenesulfonamides in Solid, Solution and Gas Phases.
Rajeev, Kallanthottathil G.,Shashidhar, Srikantiah M.,Pius, Kuruvilla,Bhatt, Vivekananda M.
, p. 5425 - 5438 (2007/10/02)
The reaction of 2-formylbenzenesulfonyl chloride 1 and its pseudo isomer 2 with primary amines give either the corresponding sulfonamido Schiff bases or the corresponding 2-formylbenzenesulfonamide depending on the concentration of the amine used.These derivatives exist as an equilibrium mixture of the corresponding sulfonamide and 2-alkyl-3-hydroxy(or 3-aminoalkyl)-benzisothiazole-1,1-dioxide.Spectroscopic studies suggest that 2-formylbenzenesulfonamides exist as benzisothiazole-1,1-dioxides in the solid state, as a mixture of 2-formylbenzenesulfonamide and the corresponding benzisothiazole-1,1-dioxide in solution and as 2-formyl-benzenesulfonamides in the gas phase.
