21639-41-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Formylbenzenesulfonyl chloride is used as a key intermediate in the synthesis of various pharmaceuticals. Its reactivity allows for the formation of amides and sulfonamides, which are essential components in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Formylbenzenesulfonyl chloride is employed as a building block for the creation of agrochemicals. Its ability to form amides and sulfonamides contributes to the development of effective pesticides and other agricultural chemicals.
Used in Dye and Pigment Production:
2-Formylbenzenesulfonyl chloride is used as a starting material in the production of dyes and pigments. Its chemical properties enable the synthesis of a wide range of colorants used in various industries, including textiles, plastics, and printing inks.
Used in Polymer Industry:
In the polymer industry, 2-Formylbenzenesulfonyl chloride is utilized as a monomer or a reactant in the synthesis of polymers with specific properties. Its versatility in organic synthesis allows for the development of polymers with tailored characteristics for various applications.
Used in Research and Development:
2-Formylbenzenesulfonyl chloride is also used in research and development settings for exploring new chemical reactions and synthesizing novel compounds. Its reactivity and ability to form amides and sulfonamides make it a valuable tool for advancing scientific knowledge and discovering new applications in various fields.

InChI:InChI=1/C7H5ClO3S/c8-12(10,11)7-4-2-1-3-6(7)5-9/h1-5H

Upstream product

• 1008-72-6 sodium 2-formylbenzenesulfonate 
• 91-25-8 2-sulfobenzaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 
• 34824-58-3 2-(2-bromophenyl)-1,3-dioxolan 
• 1523415-79-3 2-(1,3-dioxolan-2-yl)benzenesulfonyl chloride 
• 515-42-4 sodium phenylsulfonate 
• 68-12-2 N,N-dimethyl-formamide 
• 21639-39-4 2H-1,2,3-benzothiadiazine 1,1-dioxide 

Downstream Products

• 156781-20-3 2-(bis-acetoxymethyl)phenylsulfonyl chloride 
• 106939-89-3 (p-methoxyphenyl) 2-formylbenzenesulfonate 
• 21639-39-4 2H-1,2,3-benzothiadiazine 1,1-dioxide 

Relevant academic research and scientific papers

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB—Utilizing a Reversible Covalent Tethering Approach

Protein-protein modulation has emerged as a proven approach to drug discovery. While significant progress has been gained in developing protein-protein interaction (PPI) inhibitors, the orthogonal approach of PPI stabilization lacks established methodologies for drug design. Here, we report the systematic ″bottom-up″ development of a reversible covalent PPI stabilizer. An imine bond was employed to anchor the stabilizer at the interface of the 14-3-3/p65 complex, leading to a molecular glue that elicited an 81-fold increase in complex stabilization. Utilizing protein crystallography and biophysical assays, we deconvoluted how chemical properties of a stabilizer translate to structural changes in the ternary 14-3-3/p65/molecular glue complex. Furthermore, we explore how this leads to high cooperativity and increased stability of the complex.

SULFONAMIDE OR AMIDE COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PROPHYLAXIS AND/OR TREATMENT OF AUTOIMMUNE, INFLAMMATION OR INFECTION RELATED DISORDERS

The present invention related to novel sulfonamides or amides as TLR-4 antagonists, and pharmaceutical formulations containing the same and the methods of use thereof. Uses of the present novel sulfonamides or amides include, but are not limited to, the prophylaxis and/or treatment of autoimmune, inflammation, or infection related disorders.

Synthesis of 4-unsubstituted 2H-1,2,3-benzothiadiazine 1,1-dioxides via ortho lithiation of protected benzaldehyde derivatives

Variously substituted 2-phenyl-1,3-dioxolanes and 2-(2-bromophenyl)-1,3- dioxolanes, prepared from the corresponding benzaldehydes, were lithiated ortho to the acetal group. Reaction of the lithio derivatives with sulfur dioxide led to the lithium sulfinate salts, which gave, upon oxidative chlorination with sulfuryl chloride, the corresponding benzenesulfonyl chlorides. Then, depending on the aromatic substitution pattern of the molecule, several protocols were elaborated for the functional group transformations leading to the target compounds. Ring closure was performed with hydrazine hydrate or acetylhydrazine, in the latter case with one-pot removal of the acetyl group. The 4-unsubstituted 2H-1,2,3-benzothiadiazine 1,1-dioxides thus obtained are potential drug candidates based on their structural similarity to biologically active phthalazinones.

NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS

Disclosed are compounds of Formula (I): (I) which are useful as bromodomain inhibitors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are bromodomain-dependent are also disclosed. Methods for preparing and using these compounds are further described.

New CRTH2 Antagonists

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

NOVEL CURCUMIN DERIVATIVE

To develop a highly safe measure to treat Alzheimer's disease using a secretase-inhibiting substance, there is provided a compound represented by the following general formula (I) or a salt thereof: wherein A represents a phenyl group or the like, R1 represents a chlorine atom, a bromine atom, or a nitro group or the like, R2, R3, R4, and R5 each represent a hydrogen atom or the like, and L represents CH2—CH2 or CH═CH.

CRTH2 MODULATORS

Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I

NOVEL CURCUMIN DERIVATIVE

The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Aβ aggregation, a degradative effect on Aβ aggregates, an inhibitory effect on β-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.

2-Substituted and 4-substituted aryl nitrone compounds

The present invention provides aryl nitrones, compositions comprising the same and methods of their use for the treatment or prevention of oxidative, ischemic, ischemia/reperfusion-related and chemokine mediated conditions.

Synthesis and evaluation of novel thiazolidine derivatives as thromboxane A2 receptor antagonists

A series of 3-benzoyl or 3-phenylsulfonyl-2-substituted thiazolidine derivatives were synthesized, and evaluated for their thromboxane A2 (TXA2) receptor-antagonizing effect on (15S)-15-hydroxy-11α,9α- (epoxymethano)prosta-5(Z),13(E)-dienoic acid (U-46619)-induced aggregation of rabbit platelet-rich plasma (PRP). A simple 2-arylthiazolidine derivative, 3- benzoyl-2-(4-hydroxy-3-methoxyphenyl)thiazolidine (5a), showed mild TXA2 receptor antagonist activity. Modification of 5a led to 2-chloro-4-[3-(4- chlorophenylsulfonyl)thiazolidin-2-ylmethyl]phenoxyaretic acid (29d), which showed 10 times more potent TXA2 receptor antagonist activity than 5a.