156361-02-3

Usage

Uses

Used in Pharmaceutical Research and Development:
6-AMINO-5-CHLORO-NICOTINONITRILE is utilized as a key intermediate in the synthesis of new drugs, targeting the treatment of various diseases. Its unique chemical structure allows for the development of active pharmaceutical ingredients with novel therapeutic properties.
Used in Agrochemical Production:
6-AMINO-5-CHLORO-NICOTINONITRILE is also employed in the creation of agrochemicals, contributing to the development of new materials for use in the agricultural industry to enhance crop protection and yield.
Used in Synthesis of Active Pharmaceutical Ingredients:
6-AMINO-5-CHLORO-NICOTINONITRILE is used as a precursor in the synthesis of active pharmaceutical ingredients, playing a vital role in the formulation of new medications that address unmet medical needs.
Used in Development of New Materials for Pharmaceutical and Agrochemical Industries:
Its application extends to the development of innovative materials for both the pharmaceutical and agrochemical sectors, where it aids in the creation of advanced compounds with improved efficacy and safety profiles.

InChI:InChI=1/C6H4ClN3/c7-5-1-4(2-8)3-10-6(5)9/h1,3H,(H2,9,10)

Upstream product

• 38185-55-6 5-bromo-3-chloropyridin-2-ylamine 
• 4214-73-7 6-aminonicotinonitrile 

Relevant academic research and scientific papers

Rh/Pd catalysis with chiral and achiral ligands: Domino synthesis of aza-dihydrodibenzoxepines

A game of dominoes: A synthetic route to aza-dihydrodibenzoxepines is described, through the combination of a Rh-catalyzed arylation and a Pd-catalyzed C-O coupling in a single pot. For the first time, the ability to incorporate a chiral and an achiral ligand in a two-component, two-metal transformation is achieved, giving the products in moderate to good yields, with excellent enantioselectivities. Copyright

An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]

A practical Pd(PPh3)4/DBU catalytic system for the synthesis of pharmaceutically relevant aminopyridine nitrile intermediates, as well as a variety of other aryl nitriles using non-toxic K4[Fe(CN) 6] has been developed. The key features of our new protocol for cyanation lie in that the reaction can be carried out with readily available Pd(PPh3)4 under mild and green conditions, even without the assistance of other ligands. The Royal Society of Chemistry 2012.

NOVEL BI-ARYL AMINES

The present invention relates to novel bi-aryl amines of formula (I) and to pharmaceutically acceptable prodrugs, salts, solvates, hydrates, and N-oxides thereof and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation.