1564207-35-7

Basic information

• Product Name: 2-N-(phenoxyacetyl)-8-chloro-7-deaza-2'-deoxyguanosine
• Synonyms: 2-N-(phenoxyacetyl)-8-chloro-7-deaza-2'-deoxyguanosine
• CAS NO: 1564207-35-7
• Molecular Weight: 434.836
• Mol File: 1564207-35-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-N-(phenoxyacetyl)-8-chloro-7-deaza-2'-deoxyguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-N-(phenoxyacetyl)-8-chloro-7-deaza-2'-deoxyguanosine(1564207-35-7)
• EPA Substance Registry System: 2-N-(phenoxyacetyl)-8-chloro-7-deaza-2'-deoxyguanosine(1564207-35-7)

Safety Data

• Hazardous Substances Data: 1564207-35-7(Hazardous Substances Data)

Upstream product

• 1564203-71-9 2',5'-di-O-acetyl-8-chloro-7-deaza-2'-deoxyguanosine 
• 86392-75-8 7-deaza-2'-deoxyguanosine 
• 14316-61-1 phenoxyacetic anhydride 

Downstream Products

• 1564208-29-2 C₄₉H₅₄ClN₆O₉P 

Relevant articles and documents

Synthesis of 8-halogenated-7-deaza-2′-deoxyguanosine as an 8-oxo-2′-deoxyguanosine analogue and evaluation of its base pairing properties

8-Halogenated-7-deaza-2′-deoxyguanosines (8-halo-7-deaza-dG) were designed to structurally mimic 8-oxo-2′-deoxyguanosine (8-oxo-dG), which is representative of an oxidized nucleoside. It has been shown by NMR that the conformation around the N-glycosidic bond of (8-halo-7-deaza-dG) is preferably syn, similar to 8-oxo-dG. The base pairing properties of 8-halo-7-deaza-dG were studied by measuring the thermal denaturation temperature of the duplexes, showing that their base pair with dC is destabilized compared with natural dG. These results also support their preference for syn conformation. Unlike 8-oxo-dG, 8-halo-7-deaza-dG did not form a stable base pair with dA, most likely due to the lack of N7-H hydrogen bonding with dA. In conclusion, the newly-designed 8-halo-7-deaza-dG analogs resemble 8-oxo-dG in its shape and preference for syn conformation, but they do not form Hoogsteen base pair with the opposing dA.