156424-87-2

Upstream product

• 156424-85-0 Trifluoro-acetic acid 1-(3,4-dimethoxy-phenyl)-2,3-dimethoxy-4-oxo-cyclobut-2-enyl ester 
• 156424-86-1 2,2-dimethoxy-4-(3,4-dimethoxyphenyl)-3-methoxycyclobutenone 
• 2859-78-1 4-Bromoveratrole 

Downstream Products

• 156424-90-7 6,7-bis-(3,4-dimethoxyphenyl)-1,2,3-trihydro-8-trifluoromethylsulfonyl-indolizine-5-one 
• 156424-89-4 8-hydroxy-6,7-bis-(3,4-dimethoxy)-phenyl-1,2,3-trihydroindolizine-5-one 
• 156424-91-8 6,7-bis-(3,4-dimethoxyphenyl)-1,2,3-trihydroindolizine-5-one 
• 26503-67-3 (+/-)-6,7-di(3,4-dimethoxyphenyl)-1,2,3,5,8,8a-hexahydro-indolizine 
• 156424-88-3 6,7-bis-(3,4-dimethoxyphenyl)-indolizine-5,8-dione 

Relevant academic research and scientific papers

Synthesis of (±)-septicine

The total synthesis of the indolizidine alkaloid, (±)-septicine (5) (27% overall yield) in 8 steps from dimethyl squarate is presented. The key step of the synthesis involves the ring expansion of 2,3-bis-(3,4-dimethoxyphenyl)-4-(1-pyrrolo)cyclobutenone 12 to the corresponding indolizine-5,8-dione 6. The synthesis is highly convergent and thus could be used for the synthesis of a variety of analogs.