1564263-93-9Relevant articles and documents
Palladium catalyzed acetoxylation of benzylic C-H bonds using a bidentate picolinamide directing group
Cheng, Tao,Yin, Weiyu,Zhang, Yi,Zhang, Yingnan,Huang, Yong
, p. 1405 - 1411 (2014/03/21)
A general palladium catalyzed acetoxylation of benzylic C-H bonds has been developed. Picolinamides serve as an excellent directing group for the C-H activation of benzylic methyls. A wide range of 2-amino benzyl alcohol analogues were synthesized in good yields. The products demonstrated broad synthetic utilities toward various benzo-fused heterocycles. Mechanistic studies revealed the key rate-limiting C-H insertion step, which could be affected by the substitution pattern of the parent arene.