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15644-82-3

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15644-82-3 Usage

General Description

2,6-Dimethyl-4-quinolinol, also known as Menoctone, is a chemical compound of the quinoline family. It's an organic compound with the formula C12H13NO and molecular weight of 189.24. 2,6-Dimethyl-4-quinolinol appears as off-white to beige crystalline powder and its primary use is in veterinary medicine as an anti-parasitic agent. It has been specifically utilized for the treatment of heartworm in dogs. It's soluble in alcohol, but insoluble in water. This chemical is considered a toxic substance and should be handled with appropriate safety precautions.

Check Digit Verification of cas no

The CAS Registry Mumber 15644-82-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,6,4 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 15644-82:
(7*1)+(6*5)+(5*6)+(4*4)+(3*4)+(2*8)+(1*2)=113
113 % 10 = 3
So 15644-82-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H11NO/c1-7-3-4-10-9(5-7)11(13)6-8(2)12-10/h3-6H,1-2H3,(H,12,13)

15644-82-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-dimethyl-1H-quinolin-4-one

1.2 Other means of identification

Product number -
Other names 4-Quinolinol, 2,6-dimethyl-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15644-82-3 SDS

15644-82-3Relevant articles and documents

Synthesis and identification of quinoline derivatives as topoisomerase I inhibitors with potent antipsoriasis activity in an animal model

Zhang, Wen-Jin,Li, Peng-Hui,Zhao, Min-Cong,Gu, Yao-Hao,Dong, Chang-Zhi,Chen, Hui-Xiong,Du, Zhi-Yun

, (2019/05/10)

Psoriasis is a chronic inflammatory and immune-mediated skin disease. Although certain agents have shown clinical success in treating psoriasis, development of safe and effective strategies for the treatment of this condition remains important. Research suggests that DNA topoisomerase I (Topo I)inhibitors may have potent psoriasis-ameliorating effects. Here, 25 quinoline derivatives were synthesized and identified as Topo I inhibitors. These compounds inhibited the 12–O–tetradecanoylphorbol-13-acetate-induced mouse ear inflammation. The most potent analogs, 5i and 5l, suppressed the expression of inflammatory cytokines in lipopolysaccharide-stimulated HaCaT cells. Additionally, the lead compounds significantly improved imiquimod-induced psoriasis-like inflammation in mice. Moreover, the expression levels of cytokines and inflammatory mediators, such as interleukin (IL)-17A, IL-22, IL-23, nuclear factor-κB subunit p65, tumor necrosis factor-α, and interferon-γ, were dramatically inhibited in the dorsal skin of 5i- and 5l-treated mice. These findings indicate that the inhibition of Topo I activity may potentially be an effective strategy for psoriasis treatment.

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

Luo, Wei,Liu, Yang,Wang, Jian,Guo, Chun,Lu, Wei-Qiang,Cui, Kun-Qiang

, p. 3073 - 3079,7 (2020/08/20)

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.

C-Acylation of p-Acetotoluidine in Presence of Polyphosphoric Acid

Desai, Geeta,Desai, K. K.,Desai, C. M.

, p. 370 - 371 (2007/10/02)

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