156441-99-5

Upstream product

• 156440-98-1 (2S,4R)-N-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carbaldehyde 
• 156441-98-4 (2R,4R)-1-Allyloxycarbonyl-4-hydroxy-2-(1-methyl-pyrazol-5-ylmethyl)-pyrrolidine 
• 98-91-9 thiobenzoic acid 
• 156441-97-3 (2R,4R)-1-Allyloxycarbonyl-4-(t-butyldimethylsilyloxy)-2-(1-methylpyrazol-5-ylmethyl) pyrrolidine 
• 191734-27-7 (RS)-[(2S,4R)-1-allyloxycarbonyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methylpyrazol-5-yl)methanol 
• 351529-73-2 (RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methylpyrazol-5-yl)methanol 

Downstream Products

• 164161-74-4 (2R,4S)-2-(2-Methyl-2H-pyrazol-3-ylmethyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems. Part IV. 2-Alkyl substituents containing cationic heteroaromatics linked via a C-C bond

The synthesis and biological activity of a novel series of 2-alkyl-4-pyrrolidinylthio-β-methylcarbapenems containing a variety of cationic heteroaromatic substituents linked via a C-C bond is described. As a result of these studies, we selected FR21818 (1

Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents

A compound of the formula: STR1 in which R1 is carboxy or protected carboxy, R2 is 1-hydroxyethyl, R3 is methyl, R4 is optionally substituted pyridyl(lower)alkyl, optionally N-substituted 2-oxopiperazin-1-yl-(lo

Studies on β-lactam antibiotics, synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs

The synthesis and biological activity of the novel series of 1β-methylcarbapenems 1 are described. Most compounds displayed extremely potent antibacterial activity and high renal DHP-I stability. The best compound in this series, FR21818 (1a) displayed ex