164161-74-4

Upstream product

• 191734-27-7 (RS)-[(2S,4R)-1-allyloxycarbonyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methylpyrazol-5-yl)methanol 
• 156441-99-5 (2R,4S)-1-Allyloxycarbonyl-4-benzoylthio-2-(1-methylpyrazol-5-ylmethyl)-pyrrolidine 
• 351529-73-2 (RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methylpyrazol-5-yl)methanol 
• 156441-97-3 (2R,4R)-1-Allyloxycarbonyl-4-(t-butyldimethylsilyloxy)-2-(1-methylpyrazol-5-ylmethyl) pyrrolidine 
• 156440-98-1 (2S,4R)-N-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carbaldehyde 
• 76-83-5 trityl chloride 
• 171012-50-3 (2R,4S)-4-Mercapto-2-(2-methyl-2H-pyrazol-3-ylmethyl)-pyrrolidine-1-carboxylic acid allyl ester 

Relevant academic research and scientific papers

Studies on β-lactam antibiotics, synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs

The synthesis and biological activity of the novel series of 1β-methylcarbapenems 1 are described. Most compounds displayed extremely potent antibacterial activity and high renal DHP-I stability. The best compound in this series, FR21818 (1a) displayed ex