156458-78-5

Usage

Uses

thiazolidin e thione pharmaceutical intermediate

Upstream product

• 134469-06-0 thiazolidine-2-thione 
• 3739-94-4 2,6-Pyridinedicarbonyl dichloride 

Downstream Products

• 373614-45-0 N²,N⁶'-bis(2-aminophenpy)pyridine-2,6-dicarboximide 
• 1429988-58-8 15,18,50,53-tetramethyl-14,19,49,54-tetraphenyl-3,11,22,30,38,46,57,65,71,72,73,74,75,76-tetradecaazaundecacyclo[65.3.1.1(13,16).1(17,20).1(32,36).1(48,51).1(52,55).0(5,10).0(23,28).0(40,45).0(58,63)]hexaheptaconta-1⁽⁷¹⁾,5,7,9,13,15,17,19,23⁽²⁸⁾,24,26,32⁽⁷⁴⁾,33,35,40⁽⁴⁵⁾,41,43,48,50,52,54,58,60,62,67,69-hexacosaen-2,12,21,31,37,47,56,66-octone 

Relevant academic research and scientific papers

Desymmetrization reactions: A convenient synthesis of aromatic diamide diamines

A two-step process for the synthesis of various diamide diamines derived from 1,n-diamino benzene compounds is described. The amidation reaction is simple, mild, involves readily available bis(N-acylthiazolidine-2-thione) derivatives as acylating agents and requires only stoichiometric equivalents of diamine and acylating agents.

Synthesis of macrocyclic polyhydroxy tetralactams derived from L-tartaric acid and β-hydroxyglutaric acid

The synthesis of new 16-, 18-, 19- or 20-membered secondary tetralactams with L-tartaric acid or β-hydroxyglutaric acid moieties is investigated. The stepwise synthesis with an intermediate diamide diamine provides overall good yields (30-55%) compared with other processes using an intermediate diamide diacid or direct macrocyclization. This synthetic pathway leads to symmetrical or unsymmetrical polyhydroxytetralactams with variable hydroxyl group number. Use of mild acylating agents in this approach allows to avoid the protection-deprotection steps of hydroxyl groups.