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6342-56-9 Usage


Methylglyoxal 1,1-dimethyl acetal is an organic compound that serves as a synthetic reagent and precursor in the preparation of various pharmaceutical agents and compounds.


Used in Pharmaceutical Industry:
Methylglyoxal 1,1-dimethyl acetal is used as a synthetic reagent for the preparation of MCL1 inhibitors S63845, which are tolerable and effective in diverse cancer models. This makes it a valuable component in the development of cancer treatments.
Used in Neurodegenerative Disorder Research:
Methylglyoxal 1,1-dimethyl acetal is also used as a synthetic reagent for the preparation of novel 2,4-disubstituted pyrimidines. These compounds act as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. The selective inhibition of neuronal nitric oxide synthase is an important therapeutic approach to target neurodegenerative disorders, making Methylglyoxal 1,1-dimethyl acetal instrumental in the research and treatment of such conditions.
Used in Chemical Synthesis:
Methylglyoxal 1,1-dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. This process highlights its utility in chemical synthesis for various applications.
Used in Enzyme Research:
Methylglyoxal 1,1-dimethyl acetal was utilized to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability, and enzyme activity of yeast enolase in vivo. This application underscores its role in understanding the impact of glycation on enzyme function and stability.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 2642, 1976 DOI: 10.1021/jo00877a030

Check Digit Verification of cas no

The CAS Registry Mumber 6342-56-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,4 and 2 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6342-56:
89 % 10 = 9
So 6342-56-9 is a valid CAS Registry Number.

6342-56-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Detail
  • Alfa Aesar

  • (B24988)  Pyruvic aldehyde dimethyl acetal, 97+%   

  • 6342-56-9

  • 100g

  • 414.0CNY

  • Detail
  • Alfa Aesar

  • (B24988)  Pyruvic aldehyde dimethyl acetal, 97+%   

  • 6342-56-9

  • 500g

  • 1350.0CNY

  • Detail
  • Aldrich

  • (170216)  Methylglyoxal1,1-dimethylacetal  ≥97%

  • 6342-56-9

  • 170216-100ML

  • 250.38CNY

  • Detail
  • Aldrich

  • (170216)  Methylglyoxal1,1-dimethylacetal  ≥97%

  • 6342-56-9

  • 170216-500ML

  • 1,020.24CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name Methylglyoxal 1,1-dimethyl acetal

1.2 Other means of identification

Product number -
Other names Pyruvaldehyde, 1-(dimethyl acetal)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6342-56-9 SDS

6342-56-9Relevant articles and documents

Preparation method of pyruvic aldehyde glycol


Paragraph 0085-0087; 0090; 0091; 0098; 0099; ..., (2021/10/13)

The invention relates to a method for preparing pyruvic aldehyde glycol, which comprises the following step of: reacting 1, 3-dihydroxy acetone with alcohol in the presence of a catalyst to obtain the pyruvic aldehyde glycol.

Synthesis of Sn-Beta with Exclusive and High Framework Sn Content

Van Der Graaff, William N. P.,Li, Guanna,Mezari, Brahim,Pidko, Evgeny A.,Hensen, Emiel J. M.

, p. 1152 - 1160 (2015/04/14)

Sn-Beta zeolite was prepared by acid dealumination of Beta zeolite, followed by dehydration and impregnation with anhydrous SnCl4. The formation of extraframework Sn (EFSn) species was prevented by the removal of unreacted SnCl4 in a methanol washing step prior to calcination. The resulting Sn-Beta zeolites were characterized by X-ray diffraction, Ar physisorption, NMR, UV/Vis, and FTIR spectroscopy. These well-defined Lewis acid zeolites exhibit good catalytic activity and selectivity in the conversion of 1,3-dihydroxyacetone to methyl lactate. Their performance is similar to a reference Sn-Beta zeolite prepared by hydrothermal synthesis. Sn-BEA zeolites that contain EFSn species exhibit lower catalytic activity; the EFSn species also catalyze formation of byproducts. DFT calculations show that partially hydrolyzed framework Sn-OH species (open sites), rather than the tetrahedral framework Sn sites (closed sites), are the most likely candidate active sites for methyl lactate formation.

Efficient preparation of α-ketoacetals

Ayala-Mata, Francisco,Barrera-Mendoza, Citlalli,Jimenez-Vazquez, Hugo A.,Vargas-Diaz, Elena,Zepeda, L. Gerardo

, p. 13864 - 13878 (2013/03/13)

The Weinreb amides 2a,b were prepared from the a,a-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded a-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.

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