156459-87-9

Upstream product

• 1501-04-8 Methyl 4-benzoylbutanoate 
• 1501-05-9 5-oxo-5-phenylvaleric acid 
• 108-55-4 glutaric anhydride, 

Downstream Products

• 112607-34-8 (6S) 6-phenyltetrahydro-2H-pyran-2-one 
• 160413-04-7 (2'S,2''S,6'S,6''S) 1-O,6-O-(6,6'-diphenyl-3,3',4,4',5,5',6,6'-octahydro-2,2'-bi-2H-pyran-2,2'-diyl)-2-O,3-O,4-O,5-O-tetrabenzyl-D-myo-inositol 
• 160413-02-5 (2'S,2''S,6'S,6''S) 2-O,5-O-dibenzoyl-1-O,6-O-(6,6'-diphenyl-3,3',4,4',5,5',6,6'-octahydro-2,2'-bi-2H-pyran-2,2'-diyl)-D-myo-inositol 
• 154859-09-3 (6S,6'S)-6,6'-Diphenyl-5,6,5',6'-tetrahydro-4H,4'H-[2,2']bipyranyl 

Relevant academic research and scientific papers

Efficient Stereoselective Synthesis of Structurally Diverse γ- and δ-Lactones Using an Engineered Carbonyl Reductase

Structurally diverse γ- and δ-lactones were efficiently synthesized stereoselectively using an engineered carbonyl reductase from Serratia marcescens (SmCRV4). SmCRV4 exhibited improved activity (up to 500-fold) and thermostability toward 14 γ-/δ-keto acids and esters, compared with the wild-type enzyme, with 110-fold enhancement in catalytic efficiency (kcat/Km) toward methyl 4-oxodecanoate. The preparative synthesis of alkyl and aromatic γ- and δ-lactones with 95 %–>99 % ee and 78 %–90 % yields was demonstrated. The highest space-time yield, 1175 g L?1 d?1, was achieved for (R)-γ-decalactone.

Inhibiting prolyl isomerase activity by hybrid organic-inorganic molecules containing rhodium(II) fragments

A small molecule containing a rhodium(II) tetracarboxylate fragment is shown to be a potent inhibitor of the prolyl isomerase FKBP12. The use of small molecules conjugates of rhodium(II) is presented as a general strategy for developing new protein inhibi

Dispiroketals in Synthesis (Part 19): Dispiroketals as Enantioselective and Regioselective Protective Agents for Symmetric Cyclic and Acyclic Polyols.

The enantioselective preparation of both enantiomers of a C2-symmetric diphenyl-bidihydropyran 3 and 4 is described.The application of enantiopure bi-dihydropyrans 1-4 towards the simultaneous enantioselective differentiation and regioselective protection of a range of cyclic and acyclic symmetrical polyols (23, 37, 43, 45, 54, 61 and 66) is investigated.Several deprotections utilising trifluoroacetic acid (TFA) and a transketalisation with acidic glycerol are presented.