1501-05-9Relevant articles and documents
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Anderson,A.G. et al.
, p. 1445 - 1450 (1973)
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Gresham et al.
, p. 2345 (1951)
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Mislow,Lazarus
, p. 6383 (1955)
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A general and versatile synthesis of 4- and 5-oxoacids
Lhommet,Freville,Thuy,Petit,Celerier
, p. 3897 - 3901 (1996)
The condensation of Grignard reagents with succinic or glutaric anhydrides in presence of a catalytic amount of CuI is a good way for the preparation of 4- or 5-oxoacids.
Design, synthesis and in vitro anti-tuberculosis activity of benzo[6,7]cyclohepta[1,2-b]pyridine-1,2,3-triazole derivatives
Sajja, Yasodakrishna,Vanguru, Sowmya,Vulupala, Hanmanth Reddy,Bantu, Rajashaker,Yogeswari, Perumal,Sriram, Dharmarajan,Nagarapu, Lingaiah
, p. 5119 - 5121 (2017)
A series of novel benzo[6,7]cyclohepta[1,2-b]pyridine-1,2,3-triazole hybrids (7a–j & 8a–j) have been designed and synthesized in excellent yields by Huisgen's [3+2] cyclo addition reaction of 3-(azidomethyl)-2-methyl-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]pyridine (5) with various alkynes 6 in presence of copper sulphate and sodium ascorbate and their structures were confirmed by IR, 1H NMR, 13C NMR and HRMS. The newly synthesized compounds 7a–j & 8a–j were evaluated for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). Among the compounds tested, the compounds 7i and 8g displayed most potent activity with MIC value of 1.56 μg/mL with low cytotoxicity.
Nitroxyl Catalysts for Six-Membered Ring Bromolactonization and Intermolecular Bromoesterification of Alkenes with Carboxylic Acids
Moriyama, Katsuhiko,Kuramochi, Masako,Tsuzuki, Seiji,Fujii, Kozo,Morita, Takeshi
supporting information, p. 268 - 273 (2021/01/09)
We developed a nitroxyl-catalyzed bromoesterification of alkenes with bromo reagents, which includes a six-membered ring bromolactonization of alkenyl carboxylic acids catalyzed by AZADO as the nitroxyl radical catalyst, and an intermolecular bromoesterification of alkenes with carboxylic acids using NMO as the N-oxide catalyst. We also accomplished a remote diastereoselective bromohydroxylation via an AZADO-catalyzed six-membered ring bromolactonization and a subsequent ring cleavage reaction with alkylamines to furnish ?-bromo-δ-hydroxy amides with high diastereoselectivity.
Asymmetric hydrogenation reaction γ - or δ - ketonato compound (by machine translation)
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Paragraph 0048-0050, (2020/03/06)
The invention relates to the field, of organic chemistry, specifically γ - or δ - keto acid compound asymmetric hydrogenation reaction, reaction formula as follows : Wherein R is H,C. 1 - C6 An alkyl or halogen, is R 1 - 5 in number of substituents . wherein n is 1 or 2;Cat. is a chiral spiro pyrimidyl phosphine ligand iridium complex . and γ - or δ - keto acid compound is subjected to an internal esterification reaction to further prepare a lactone compound. (by machine translation)
