156480-30-7Relevant academic research and scientific papers
EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS
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, (2008/06/13)
The invention features a method of treating rheumatoid arthritis in a mammal comprising administering an agent that inhibits prostaglandin EP4 receptor (EP4) activity. Also featured is a method of identifying agents that selectively inhibit EP4 activity in vivo.
Vicarious nucleophilic substitution of nitrobenzenes : Application of the reaction to 2-alkylnitrobenzenes
DeBoos,Milner
, p. 965 - 976 (2007/10/02)
Vicarious nucleophilic substitution (VNS) by dichloroacetate and other reagents has been applied in good yield to various ortho-substituted nitrobenzenes including 2-nitrotoluene and 2-nitro ethylbenzene. For alkyl nitrobenzenes, ease of VNS increased para ortho meta and methyl ethyl iso-propyl. Formation of chlorine-free products upon VNS by methyl dichloro- acetate suggests the involvement of radical anions.
