156483-09-9Relevant academic research and scientific papers
Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-k{cyrillic}B and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer ag
Giri, Rajan S.,Thaker, Hardik M.,Giordano, Tony,Williams, Jill,Rogers, Donna,Vasu, Kamala K.,Sudarsanam, Vasudevan
experimental part, p. 2796 - 2808 (2010/07/06)
In an attempt to discover novel inhibitors of NF-κB and AP-1 mediated transcriptional activation utilizing the concept of chemical lead based medicinal chemistry and bioisosterism a series of 2-(2,3-disubstituted-thiophen-5-yl)-3H-quinazolin-4-one analogs
Synthesis, anticonvulsant activity, and structure-activity relationships of sodium channel blocking 3-aminopyrroles
Unverferth, Klaus,Engel, Jürgen,H?fgen, Norbert,Rostock, Angelika,Günther, Ralf,Lankau, Hans-Joachim,Menzer, Manfred,Rolfs, Andreas,Liebscher, Jürgen,Müller, Birgit,Hofmann, Hans-J?rg
, p. 63 - 73 (2007/10/03)
Starting from the corresponding acetophenone and glycine derivatives, a series of new 3-aminopyrroles was synthesized in few steps. Using this procedure with hydrazine and hydroxylamine instead of the glycinates provides access to 3-aminopyrazoles and 5-a
Efficient synthesis of 3-aminothioacrylamides by iminoformylation of thioacetamides
Rolfs,Liebscher
, p. 683 - 684 (2007/10/02)
Heating substituted thioacetamides 1 with either trismorpholinomethane or with a mixture of triethyl orthoformate and a secondary amine gives high yields of synthetically versatile 3-aminothioacrylamides 4.
