42945-85-7

Basic information

• Product Name: Ethanethione, 2-(4-chlorophenyl)-1-(4-Morpholinyl)-
• Synonyms: Ethanethione, 2-(4-chlorophenyl)-1-(4-Morpholinyl)-;2-(4-chlorophenyl)-1-(4-morpholinyl)Ethanethione
• CAS NO: 42945-85-7
• Molecular Formula: C₁₂H₁₄ClNOS
• Molecular Weight: 255.76366
• Mol File: 42945-85-7.mol
• Article Data: 23

Chemical Properties

• Melting Point: 98.5-99 °C
• Boiling Point: 378.6°Cat760mmHg
• Flash Point: 182.8°C
• Appearance: /
• Density: 1.276g/cm³
• Vapor Pressure: 6.21E-06mmHg at 25°C
• Refractive Index: 1.61
• PKA: 1.23±0.20(Predicted)
• CAS DataBase Reference: Ethanethione, 2-(4-chlorophenyl)-1-(4-Morpholinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanethione, 2-(4-chlorophenyl)-1-(4-Morpholinyl)-(42945-85-7)
• EPA Substance Registry System: Ethanethione, 2-(4-chlorophenyl)-1-(4-Morpholinyl)-(42945-85-7)

Safety Data

• Hazardous Substances Data: 42945-85-7(Hazardous Substances Data)

Usage

General Description

Ethanethione, 2-(4-chlorophenyl)-1-(4-Morpholinyl)-, also known as thiofentanyl, is a potent synthetic opioid that acts as an analgesic and sedative. It is a derivative of fentanyl, a powerful opioid pain medication, and has a similar chemical structure. Thiofentanyl is a Schedule I controlled substance in the United States and is not approved for medical use. It is primarily used as a research chemical and has been associated with a number of fatalities and overdoses. Its high potency and potential for abuse make it a dangerous substance with significant public health risks.

InChI:InChI=1/C12H14ClNOS/c13-11-3-1-10(2-4-11)9-12(16)14-5-7-15-8-6-14/h1-4H,5-9H2

Upstream product

• 110-91-8 morpholine 
• 1073-67-2 4-vinylbenzyl chloride 
• 99-91-2 para-chloroacetophenone 
• 57495-15-5 1‐(4‐chlorophenyl)‐2‐morpholino‐2‐thioxoethan‐1‐one 
• 1956-39-4 4-chloroacetophenone oxime 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 156483-09-9 2-(4-chlorophenyl)-1,3-di(morpholin-4-yl)propenethione 
• 1878-66-6 4-chlorophenylacetic Acid 
• 17293-69-5 methyl 2-(4-chlorophenyl)ethanethionate 
• 84300-56-1 (E)-2-(4-Chloro-phenyl)-3-hydroxy-1-morpholin-4-yl-propenethione 
• 1393898-11-7 4-(4-chlorophenyl)-5-(morpholin-4-yl)-3-phenylthiophen-2(3H)-one 
• 84300-52-7 (E)-2-(4-Chloro-phenyl)-3-dimethylamino-1-morpholin-4-yl-propenethione 
• 57495-15-5 1‐(4‐chlorophenyl)‐2‐morpholino‐2‐thioxoethan‐1‐one 
• 161895-17-6 (Z)-2-(4-chloro-phenyl)-1,3-dimorpholin-4-yl-propenethione 
• 99931-95-0 2-(4-chlorophenyl)-1-morpholinoethanone 

Relevant articles and documents

Preparation method of phenyl crotonic acid ester compound

The invention relates to the technical field of organic synthesis, in particular to a preparation method of a phenyl crotonate compound, the preparation method comprises the following steps: S1, carrying out Willgerodt-Kindler reaction on an acetophenone

Selective reduction of carbonyl groups in the presence of low-valent titanium reagents

The chemoselective reduction of several structurally diverse compounds containing carbonyl groups was achieved in the presence of low-valent titanium reagents. This novel synthetic method provides easy access to highly selective reduction of carbonyl groups, and possesses several advantages including one-step procedure, convenient manipulation, good to excellent yields, and short reaction times.

Sulfated tungstate: A green catalyst for synthesis of thiomorpholides via Willgerodt-Kindler reaction

Use of sulfated tungstate as an efficient, green and reusable catalyst for preparation of thiomorpholides via Willgerodt-Kindler reaction pathway is presented. The reaction proceeds under solvent free condition. The advantages of this method are high yiel