156496-63-8Relevant academic research and scientific papers
A convenient rearrangement of 1-phenylpyrrole-2-carboxaldehydes into their 3-isomers
Dallemagne,Rault,Fabis,Dumoulin,Robba
, p. 1855 - 1857 (1994)
1-Phenylpyrrole-2-carboxaldehydes are selectively and in high yield converted by treatment with trifluoromethanesulfonic acid (triflic acid) to 1-phenylpyrrole-3-carboxaldehydes.
Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT 7 receptor ligands
Paillet-Loilier, Magalie,Fabis, Frederic,Lepailleur, Alban,Bureau, Ronan,Butt-Gueulle, Sabrina,Dauphin, Francois,Delarue, Catherine,Vaudry, Hubert,Rault, Sylvain
, p. 3753 - 3757 (2007/10/03)
Virtual screening studies have identified a series of phenylpyrroles as novel 5-HT7 receptor ligands. The synthesis and the affinity for the 5-HT7 receptor of these phenylpyrroles are described. Some of these compounds exhibited high affinity for the 5-HT7 receptors.
Novel HIV-1 protease inhibitors active against multiple PI-Resistant viral strains: Coadministration with indinavir
Kevin, Nancy J.,Duffy, Joseph L.,Kirk, Brian A.,Chapman, Kevin T.,Schleif, William A.,Olsen, David B.,Stahlhut, Mark,Rutkowski, Carrie A.,Kuo, Lawrence C.,Jin, Lixia,Lin, Jiunn H.,Emini, Emilio A.,Tata, James R.
, p. 4027 - 4030 (2007/10/03)
HIV-1 protease inhibitors (PI) with an N-arylpyrrole moiety in the P 3 position afforded excellent antiviral potency and substantially improved aqueous solubility over previously reported variants. The rapid in vitro clearance of these compounds in human liver microsomes prompted oral coadministration with indinavir to hinder their metabolism by the cyctochrome P450 3A4 isozyme and allow for in vivo PK assessment.
