156570-15-9

Basic information

• Product Name: 1H-1,2,4-Triazole, 1-[2-(2,4-difluorophenyl)-2-propenyl]-
• CAS NO: 156570-15-9
• Molecular Formula: C11H9F2N3
• Molecular Weight: 221.209
• Mol File: 156570-15-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-1,2,4-Triazole, 1-[2-(2,4-difluorophenyl)-2-propenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazole, 1-[2-(2,4-difluorophenyl)-2-propenyl]-(156570-15-9)
• EPA Substance Registry System: 1H-1,2,4-Triazole, 1-[2-(2,4-difluorophenyl)-2-propenyl]-(156570-15-9)

Safety Data

• Hazardous Substances Data: 156570-15-9(Hazardous Substances Data)

Upstream product

• 288-88-0 1,2,4-Triazole 
• 159276-58-1 1-(1-Bromomethyl-vinyl)-2,4-difluoro-benzene 

Downstream Products

• 141113-42-0 (S)-1-((2-(2,4-difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole 
• 149809-38-1 (R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol 
• 149809-43-8 (2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran 
• 124627-86-7 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole 
• 132507-89-2 (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol 
• 118689-07-9 (S)-(+)-2(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol 

Relevant articles and documents

Preparation method of posaconazole intermediate

The invention relates to the technical field of medicine preparation, and especially relates to a preparation method of a posaconazole intermediate. The preparation method comprises the following steps: reacting a compound as shown in a formula II, serving as a raw material, with 1, 2, 4-triazole to obtain a compound as shown in a formula III, and then reacting with air or oxygen under the action of a catalyst 1 to obtain a compound as shown in a formula IV; reacting the compound as shown in the formula IV with dimethyl malonate to obtain a compound as shown in a formula V; reacting the compound shown in the formula V under the action of a reducing agent to obtain a compound shown in a formula VI; and finally, carrying out intramolecular etherification reaction on the compound shown in the formula VI, and carrying out sulfonylation reaction on the obtained product to obtain a target product I. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, few reaction steps, high yield and high purity of the obtained product.