1565852-71-2Relevant academic research and scientific papers
Alkynyliodonium salt mediated alkynylation of azlactones: Fast access to Cα-tetrasubstituted α-amino acid derivatives
Finkbeiner, Peter,Weckenmann, Nicole M.,Nachtsheim, Boris J.
, p. 1326 - 1329 (2014/04/03)
An efficient electrophilic alkynylation of azlactones (oxazol-5(4H)-ones) is developed using alkynyl(phenyl)iodonium salts as the electrophilic alkyne source. After remarkably short reaction times, the desired alkyne functionalized azlactones are obtained in 60-97% yield and can be transformed easily into a variety of quaternary α-amino acid derivatives.
