22887-54-3

Basic information

• Product Name: 5(4H)-Oxazolone, 2-(4-chlorophenyl)-4-methyl-
• CAS NO: 22887-54-3
• Molecular Formula: C10H8ClNO2
• Molecular Weight: 209.632
• Mol File: 22887-54-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 5(4H)-Oxazolone, 2-(4-chlorophenyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Oxazolone, 2-(4-chlorophenyl)-4-methyl-(22887-54-3)
• EPA Substance Registry System: 5(4H)-Oxazolone, 2-(4-chlorophenyl)-4-methyl-(22887-54-3)

Safety Data

• Hazardous Substances Data: 22887-54-3(Hazardous Substances Data)

Upstream product

• 128062-24-8 rac-ethyl 2-(4-chlorobenzamido)propanoate 
• 122-01-0 4-chloro-benzoyl chloride 
• 108462-95-9 rac-2-(4-chlorobenzamido)propanoic acid 

Downstream Products

• 108463-00-9 4-Chloro-N-(1-cyclohexyl-3,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyridin-3-yl)-benzamide 
• 85380-78-5 4-Chloro-N-(3-methyl-2-oxo-1,4-diphenyl-1,2,3,4-tetrahydro-pyridin-3-yl)-benzamide 
• 85393-35-7 4-Chloro-N-(3-methyl-2-oxo-4-phenyl-1-p-tolyl-1,2,3,4-tetrahydro-pyridin-3-yl)-benzamide 
• 85380-79-6 4-Chloro-N-[1-(4-chloro-phenyl)-3-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyridin-3-yl]-benzamide 
• 85380-80-9 4-Chloro-N-[1-(4-methoxy-phenyl)-3-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyridin-3-yl]-benzamide 
• 142779-77-9 5-p-chlorobenzoylamino-4-dimethylamino-1,2-diphenyl-5-methyl-4-methylthio-1,4,5,6-tetrahydropyrimidin-6-one 
• 142779-71-3 5-p-chlorobenzoylamino-1,2-diphenyl-5-methyl-4-methylthio-4-morpholino-1,4,5,6-tetrahydropyrimidin-6-one 
• 142779-67-7 5-p-chlorobenzoylamino-4-dimethylamino-5-methyl-2-methylthio-1-p-tolyl-1,4,5,6-tetrahydropyrimidin-6-one 
• 137441-43-1 5-(4-Chlorobenzoylamino)-4-dimethylamino-1,2-diphenyl-5-methyl-1,4,5,6-tetrahydropyrimidin-6-one 
• 137441-44-2 5-p-chlorobenzoylamino-4-dimethylamino-5-methyl-2-phenyl-1-p-tolyl-1,4,5,6-tetrahydropyrimidin-6-one 
• 112342-06-0 2-phenyl-3-methyl-5-p-chlorophenyl-Δ⁴-1,2,4-oxadiazolin-3-carboxylic acid 
• 112342-12-8 2-phenyl-3-methyl-5-p-chlorophenyl-Δ⁴-1,2,4-oxadiazolin-3-carboxylic acid methyl ester 

Relevant articles and documents

Group-Assisted Purification Chemistry for Asymmetric Mannich-type Reaction of Chiral N-Phosphonyl Imines with Azlactones Leading to Syntheses of α-Quaternary α,β-Diamino Acid Derivatives ?

An asymmetric Mannich-type reaction between chiral N-phosphonyl imines and azlactones [oxazol-5(4H)-ones] has been established under convenient conditions at room temperature. The reaction was performed without using any bases, additives, or catalysts to achieve up to excellent chemical yields and diastereoselectivity for 32 examples. The α-quaternary syn-α,β-diamino acid products were purified simply by washing the crude mixtures with cosolvents, following the group-assisted purification chemistry/technology, without involving traditional chromatography or recrystallization methods. The auxiliary can be readily removed and recycled for reuse. The absolute configuration was unambiguously assigned by X-ray structural analysis.

Bronsted acid accelerated Pd-catalyzed direct asymmetric allylic alkylation of azlactones with simple allylic alcohols: A practical access to quaternary allylic amino acid derivatives

A Bronsted acid accelerated Pd-catalyzed asymmetric allylic alkylation of azlactones with simple allylic alcohols under mild reaction conditions has been realized, which provides a direct and readily scalable approach for the synthesis of all-carbon quaternary allylic amino acid derivatives in excellent yields and good enantioselectivities. (Chemical Equation Presented).

A simple and convenient synthesis of pyrazinones

Pyrazinones were synthesized by reacting mesoionic azlactone [2-aryl-4-methyl-Δ2-oxaxolin-5-one] and 1,4-diazabutadienes in good yields at room temperature. Copyright Taylor & Francis Group, LLC.