1565871-18-2Relevant academic research and scientific papers
Iron-catalyzed four-member multicomponent reaction for assembly of (E)-6-arylvinyl-3,4-dihydropyrimidin-2(1H)-ones
Zhang, Zhiguo,Zhang, Lianqiang,Duan, Xinyu,Yan, Xiangqian,Yan, Yan,Liu, Qingfeng,Liu, Tongxin,Zhang, Guisheng
, p. 7745 - 7751 (2015/09/07)
A novel iron-catalyzed one-pot multi-component tandem reaction of acetoacetamide, urea, and two molecules of aryl aldehydes has been developed. This reaction provides a general, straightforward, practical and useful method for the preparation of potential
Iron-catalyzed vinylogous aldol condensation of biginelli products and its application toward pyrido[4,3- d ]pyrimidinones
Zhang, Lianqiang,Zhang, Zhiguo,Liu, Qingfeng,Liu, Tongxin,Zhang, Guisheng
supporting information, p. 2281 - 2288 (2014/04/03)
A novel iron-catalyzed vinylogous aldol condensation of Biginelli products with aryl aldehydes has been developed for the syntheses of potential bioactive (E)-6-arylvinyl-dihydropyrimidin-2(1H)-ones. These materials are valuable synthetic precursors to drug-like pyrido[4,3-d]pyrimidine derivatives. The amide group at the 5-position of the dihydropyrimidin-2(1H)-ones played an important role in the vinylogous aldol condensation reaction.
