333768-16-4

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 10374-66-0 3-oxo-N-phenylbutanethioamide 

Downstream Products

• 1565871-20-6 (E)-4-(4-fluorophenyl)-6-(4-methoxystyryl)-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide 
• 1565871-18-2 (E)-methyl 4-(2-(6-(4-fluorophenyl)-2-oxo-5-(phenylcarbamoyl)-1,2,3,6-tetrahydropyrimidin-4-yl)vinyl)benzoate 
• 1565871-15-9 (E)-4-(4-fluorophenyl)-2-oxo-N-phenyl-6-styryl-1,2,3,4-tetrahydropyrimidine-5-carboxamide 

Relevant academic research and scientific papers

2-acylthioacetamides in the biginelli reaction

We have demonstrated for the first time a Biginelli reaction of 2-acylthioacetamides with aromatic aldehydes and ureas or thioureas, leading to N-Ar1-4-Ar2-6-R1-1-R2-2-oxo(thioxo)- 1,2,3,4-tetrahydro-pyrimidine-5-carbothioamides. The regioselectivity of this process matched the concept of hard/soft Lewis acids and bases. It was established that nitrous acid or other oxidants converted the synthesized compounds into N-Ar1-4-Ar2-6-R1-1-R 2-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxamides, and not the expected 4-Ar2-6-R1-1-R2-5-(1,3- benzothiazol-2-yl)-1,2,3,4-tetrahydropyrimidin-2-ones(thiones).