42836-95-3

Basic information

• Product Name: 6-methyl-3-(methylsulfanyl)-1,2,4-triazine
• CAS NO: 42836-95-3
• Molecular Formula: C₅H₇N₃S
• Molecular Weight: 141.1942
• Mol File: 42836-95-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 290°C at 760 mmHg
• Flash Point: 129.2°C
• Density: 1.22g/cm³
• Vapor Pressure: 0.0037mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 6-methyl-3-(methylsulfanyl)-1,2,4-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-3-(methylsulfanyl)-1,2,4-triazine(42836-95-3)
• EPA Substance Registry System: 6-methyl-3-(methylsulfanyl)-1,2,4-triazine(42836-95-3)

Safety Data

• Hazardous Substances Data: 42836-95-3(Hazardous Substances Data)

Usage

General Description

6-methyl-3-(methylsulfanyl)-1,2,4-triazine is a chemical compound with the molecular formula C5H8N2S. It is a member of the triazine class of compounds, which are commonly used in various industrial applications such as herbicides, pesticides, and pharmaceuticals. This specific compound contains a triazine ring with a methyl group at the 6-position and a methylsulfanyl group at the 3-position. It is known to possess certain biological activities and may have potential applications in drug discovery and development. However, further research is needed to fully understand its properties and potential uses.

Upstream product

• 109307-02-0 5-chloro-6-methyl-3-(methylthio)-1,2,4-triazine 
• 1566-32-1 3-Methylthio-5-oxo-dihydro-6-methyl-1,2,4-triazin 
• 1314931-57-1 hydrazinyl(methylthio)methanamine 
• 6342-56-9 Pyruvic aldehyde dimethyl acetal 
• 35600-34-1 S-methyl isothiosemicarbazide hydroiodide 
• 78-98-8 2-oxopropanal 
• 80147-77-9 C₇H₁₅N₃O₂S 

Relevant articles and documents

CERTAIN PROTEIN KINASE INHIBITORS

Provided are compound of formula (I) as certain CDK4/6 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Synthesis and pharmacological evaluation of phenylethynyl[1,2,4] methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine

Procedures were developed for the synthesis of 3-methyl-5-phenylethynyl[1, 2,4]triazine (4), 6-methyl-3-phenylethynyl[1,2,4]triazine (5), and 5-methyl-3-phenylethynyl[1,2,4]triazine (6a) as analogues of 2-methyl-6-(phenylethynyl)pyridine (2). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro efficacy assay. The most potent of the three analogues was 6a. Twenty additional analogues of 6a were synthesized and evaluated for mGluR5 antagonist efficacy. The most potent compounds were 3-(3-methylphenylethynyl)-5-methyl[1,2, 4]triazine (6b), 5-(3-chlorophenylethynyl)-5-methyl[1,2,4]triazine (6c), and 3-(3-bromophenylethynyl)-5-methyl[1,2,4]triazine (6d).