42836-95-3

Usage

Uses

Used in Pharmaceutical Industry:
6-methyl-3-(methylsulfanyl)-1,2,4-triazine is used as a potential candidate in drug discovery and development due to its inherent biological activities. Its unique structure and properties may offer new avenues for the treatment of various diseases and conditions, although further research is required to fully explore its therapeutic potential.
Used in Agrochemical Industry:
As a member of the triazine class of compounds, 6-methyl-3-(methylsulfanyl)-1,2,4-triazine may be utilized in the development of herbicides and pesticides. Its specific structural features could provide novel mechanisms of action or improved efficacy in controlling unwanted plant growth or pests, contributing to more effective agricultural practices.

Upstream product

• 109307-02-0 5-chloro-6-methyl-3-(methylthio)-1,2,4-triazine 
• 1566-32-1 3-Methylthio-5-oxo-dihydro-6-methyl-1,2,4-triazin 
• 1314931-57-1 hydrazinyl(methylthio)methanamine 
• 6342-56-9 Pyruvic aldehyde dimethyl acetal 
• 35600-34-1 S-methyl isothiosemicarbazide hydroiodide 
• 78-98-8 2-oxopropanal 
• 80147-77-9 C₇H₁₅N₃O₂S 

Relevant academic research and scientific papers

CERTAIN PROTEIN KINASE INHIBITORS

Provided are compound of formula (I) as certain CDK4/6 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

NITROGEN HETEROCYCLE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN HUMAN THERAPEUTICS

The present invention relates to compounds having general formula I characterised in that wherein in particular: R1 represents one or a plurality of groups such as: trifluoromethyl, halogen such as F, Cl, Br, methyl, nitro. R represents nitroge

Synthesis and pharmacological evaluation of phenylethynyl[1,2,4] methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine

Procedures were developed for the synthesis of 3-methyl-5-phenylethynyl[1, 2,4]triazine (4), 6-methyl-3-phenylethynyl[1,2,4]triazine (5), and 5-methyl-3-phenylethynyl[1,2,4]triazine (6a) as analogues of 2-methyl-6-(phenylethynyl)pyridine (2). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro efficacy assay. The most potent of the three analogues was 6a. Twenty additional analogues of 6a were synthesized and evaluated for mGluR5 antagonist efficacy. The most potent compounds were 3-(3-methylphenylethynyl)-5-methyl[1,2, 4]triazine (6b), 5-(3-chlorophenylethynyl)-5-methyl[1,2,4]triazine (6c), and 3-(3-bromophenylethynyl)-5-methyl[1,2,4]triazine (6d).

Synthesis and the Crystal Structure of 4-(2-Deoxy-β-D-erythro-pentofuranosyl)-6-methyl-1,2,4-triazin-3(4H)-one 1-Oxide, a Structural Analogue of Thymidine

Condensation of pyruvaldehyde dimethyl acetal with thiosemicarbazide, followed by methylation and cyclization, gave 3-(methylthio)-6-methyl-1,2,4-triazine, which was converted to 6-methyl-1,2,4-triazin-3(4H)-one 1-oxide by treatment with sodium methoxide and by selective oxidation and hydrolysis.Following silylation, this intermediate was condensed with blocked 2-deoxyribofuranosyl chloride, providing the anomeric nucleoside mixture, which was separated and deblocked to furnish the title compound.X-ray analysis of this nucleoside was carried out to confirm its structure and to study its conformation.