1566-37-6

Basic information

• Product Name: 3-(METHYLTHIO)-6-PHENYL-1,2,4-TRIAZIN-5-OL
• Synonyms: 3-(METHYLTHIO)-6-PHENYL-1,2,4-TRIAZIN-5-OL;3-METHYLSULFANYL-6-PHENYL-[1,2,4]TRIAZIN-5-OL;3-(methylthio)-6-phenyl-1,2,4-triazin-5(2H)-one
• CAS NO: 1566-37-6
• Molecular Formula: C₁₀H₉N₃OS
• Molecular Weight: 219.26
• Mol File: 1566-37-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(METHYLTHIO)-6-PHENYL-1,2,4-TRIAZIN-5-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(METHYLTHIO)-6-PHENYL-1,2,4-TRIAZIN-5-OL(1566-37-6)
• EPA Substance Registry System: 3-(METHYLTHIO)-6-PHENYL-1,2,4-TRIAZIN-5-OL(1566-37-6)

Safety Data

• Hazardous Substances Data: 1566-37-6(Hazardous Substances Data)

Upstream product

• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 35600-34-1 S-methylisothiosemicarbazide hydriodide 
• 447-00-7 6-phenyl-1,2,4-triazine-3(2H)-thione-5(4H)-one 
• 74-88-4 methyl iodide 
• 35600-34-1 S-methylisothiosemicarbazide hydroiodide 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 6719-24-0 6-phenyl-[1,2,4]triazine-3,5-diamine 
• 61788-14-5 3-hydrazino-6-phenyl-1,2,4-triazine-5(4H)-one 
• 80809-30-9 3-amino-6-phenyl-s-triazolo<4,3-b>-as-triazin-7-one 
• 41249-59-6 3-phenylamino-5-oxo-6-phenyl-2,5-dihydro-1,2,4-triazine 
• 89988-64-7 11-methyl-3-phenyl-2H-<1,2,4>triazino<3,2-b>quinazoline-2,6(11H)-dione 
• 81941-53-9 2-amino-3-methylthio-6-phenyl-1,2,4-triazinone 
• 109307-01-9 5-chlor-3-methylthio-6-phenyl-1,2,4-triazine 
• 38119-45-8 3-(methylthio)-6-phenyl-1,2,4-triazine-5-thione 
• 89569-74-4 2-methyl<1,2,4>triazolo<2,3-b><1,2,4>triazinone 
• 89569-72-2 1-Methyl-6-phenyl-1H-[1,2,4]triazolo[1,5-b][1,2,4]triazin-7-one 
• 89569-71-1 6-Phenyl-1H-[1,2,4]triazolo[1,5-b][1,2,4]triazin-7-one 
• 89569-69-7 2-Amino-3-methylamino-6-phenyl-2H-[1,2,4]triazin-5-one 
• 89569-68-6 2,3-Diamino-6-phenyl-2H-[1,2,4]triazin-5-one 
• 85276-94-4 2-amino-4-methyl-6-phenyl-1,2,4-triazine-3,5(2H,4H)-dione 

Relevant articles and documents

TRIAZINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATION THEREOF

The invention relates to triazine derivatives of general formula (I): Wherein R1, R2 and R3 are as defined herein. The invention also relates to a method for preparing these triazine derivatives and to the therapeutic application thereof.

NEW SUBSTITUTED AZATHYMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIOUS DISEASES

The invention relates to substituted azathymidines and related compounds of formula (I), wherein X is N or CH, and R1, R2 and R3 are as described in the specification, processes for the preparation thereof, pharmaceutical compositions containing the same, the use thereof optionally in combination with one or more other pharmaceutically active compounds as antibacterial agents for the therapy of infective diseases, and a method for the treatment of such diseases. The compounds of formula (I) are reducing selectively the pathogenicity of bacteria within the host, but without affecting the bacteria outside the host environment.

INFLUENCE OF MEDIUM AND TYPE OF SUBSTITUENT ON THE YIELD OF PRODUCTS OF METHYLATION OF 4-SUBSTITUTED 1,2,4-TRIAZINE-3(2H)-THION-5(4H)-ONES

We studied the methylation of 4-R-6-R-1,2,4-triazine -3(2H)-thion-5(4H)-ones (R=H, CH3, H2N, (CH3)2NCO, C6H5NN) by methyl iodide in aqueous and aqueous-methanol solutions of NaOH.

Intramolecular Diels-Alder Reactions of 1,2,4-Triazines. Synthesis of Condensed Pyrimidines

1,2,4-Triazines with C5 tethered dienophilic side chains are sterically constrained to undergo intramolecular Diels-Alder reactions across the N2/C5 triazine positions; elimination of a nitrile from the intermediate adduct (N1 and C6 of the starting 1,2,4

Synthesis of Bridgeheaded Nitrogen Systems. s-Triazolo-as-triazine, s-Triazolo-as-triazine and s-Triazolo-1,3,4-Thiadiazole Ring Systems

By the reactions of hydrazino-as-triazines (1a-d and 5) with cyanogen bromide were synthesized s-triazolo-as-triazines (2a-d) and (6).Likewise, similar reactions of amino-s-triazolethiols (7a-e) gave s-triazolo-1,3,4-thiadiazoles (8a-d).Compound 2a was brominated to 2g.