156625-01-3

Upstream product

• 90865-70-6 [3R]-4-Benzyloxy-3-methylbutanal 
• 104410-43-7 (4R,5S)-3-(2-(benzyloxy) acetyl)-4-methyl-5-phenyloxazolidin-2-one 
• 156625-00-2 ((E)-(R)-2-Methyl-hex-4-enyloxymethyl)-benzene 
• 104372-56-7 (2R,4E)-2-Methyl-4-hexen-1-ol 
• 100-39-0 benzyl bromide 

Downstream Products

• 156625-02-4 (2R,3S,5R)-2,6-Bis-benzyloxy-3-hydroxy-5-methyl-hexanoic acid methoxy-methyl-amide 
• 156625-06-8 (3R,6R,7S,9R)-6,10-Bis-benzyloxy-7-hydroxy-3,9-dimethyl-dec-1-en-5-one 
• 156625-05-7 (6R,7S,9R)-6,10-Bis-benzyloxy-7-hydroxy-9-methyl-dec-1-en-5-one 
• 156625-10-4 (2R,4S,5S,6S,8R)-1,5-Bis-benzyloxy-2,8-dimethyl-dec-9-ene-4,6-diol 
• 156625-07-9 (2R,4S,5S,6S)-1,5-Bis-benzyloxy-2-methyl-dec-9-ene-4,6-diol 

Relevant academic research and scientific papers

Total syntheses of close analogues of the immunosuppressant FK506

The total synthesis of an analogue of FK506, in which the substituted cyclohexyl residue at C28 has been replaced by a phenyl group, is described. This synthesis demonstrates (i) the successful application of new methodology for the introduction of the masked tricarbonyl grouping (C8-C10), and (ii) new synthetic routes to the (C10-C19) and (C22-C26) regions.