156643-23-1

Basic information

• Product Name: 2-BroMo-N-(4-Methoxybenzyl)aniline, 97%
• Synonyms: 2-BroMo-N-(4-Methoxybenzyl)aniline, 97%;(2-BroMo-phenyl)-(4-Methoxy-benzyl)-aMine
• CAS NO: 156643-23-1
• Molecular Formula: C₁₄H₁₄BrNO
• Molecular Weight: 292.17106
• Mol File: 156643-23-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 68-70 °C(Solv: ethyl acetate (141-78-6); pentane (109-66-0))
• Boiling Point: 391.7±27.0 °C(Predicted)
• Appearance: /
• Density: 1.392±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.22±0.10(Predicted)
• CAS DataBase Reference: 2-BroMo-N-(4-Methoxybenzyl)aniline, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-N-(4-Methoxybenzyl)aniline, 97%(156643-23-1)
• EPA Substance Registry System: 2-BroMo-N-(4-Methoxybenzyl)aniline, 97%(156643-23-1)

Safety Data

• Hazardous Substances Data: 156643-23-1(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 615-36-1 2-bromoaniline 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 214000-45-0 C₁₄H₁₂BrNO 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1269621-20-6 6-(4-methoxybenzyl)-6H-benzo[4,5]thieno[2,3-b]indole 
• 1269620-96-3 2-(benzo[b]thiophen-3-yl)-N-(4-methoxybenzyl)aniline 
• 1269621-08-0 6-(4-methoxybenzyl)-6H-benzo[4,5]furo[2,3-b]indole 
• 1269620-92-9 2-(benzo[b]furan-3-yl)-N-(4-methoxybenzyl)aniline 
• 1047670-53-0 N-(2-bromo-phenyl)-N-(4-methoxybenzyl)-malonamic acid methyl ester 
• 156643-18-4 (2-Bromo-phenyl)-(diphenyl-phosphinoylmethyl)-(4-methoxy-benzyl)-amine 

Relevant articles and documents

Chromium-Catalyzed Alkylation of Amines by Alcohols

The alkylation of amines by alcohols is a broadly applicable, sustainable, and selective method for the synthesis of alkyl amines, which are important bulk and fine chemicals, pharmaceuticals, and agrochemicals. We show that Cr complexes can catalyze this C?N bond formation reaction. We synthesized and isolated 35 examples of alkylated amines, including 13 previously undisclosed products, and the use of amino alcohols as alkylating agents was demonstrated. The catalyst tolerates numerous functional groups, including hydrogenation-sensitive examples. Compared to many other alcohol-based amine alkylation methods, where a stoichiometric amount of base is required, our Cr-based catalyst system gives yields higher than 90 % for various alkyl amines with a catalytic amount of base. Our study indicates that Cr complexes can catalyze borrowing hydrogen or hydrogen autotransfer reactions and could thus be an alternative to Fe, Co, and Mn, or noble metals in (de)hydrogenation catalysis.

Asymmetric construction of quaternary α-nitro amides by palladium-catalyzed C(sp3)-H arylation

Pd-Catalyzed enantioselective C(sp3)-H arylation of N-(o-Br-aryl) anilides has been disclosed, and quaternary α-nitro amides were constructed with up to 98% ee. The presence of the nitro group on the substrate enables the progress of the reaction and the ready transformation of the product to optically active quaternary amino acid derivatives.

Domino palladium-catalyzed heck-intermolecular direct arylation reactions

A domino palladium-catalyzed Heck-intermolecular direct arylation reaction has been developed, giving access to a variety of dihydrobenzofurans, indolines, and oxindoles. A variety of sulfur-containing heterocycles such as thiazoles, thiophenes, and benzo