1566528-07-1

Basic information

• Product Name: 5-(3-(2-chlorophenoxy)propyl)-8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
• CAS NO: 1566528-07-1
• Molecular Weight: 358.843
• Mol File: 1566528-07-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(3-(2-chlorophenoxy)propyl)-8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-(2-chlorophenoxy)propyl)-8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole(1566528-07-1)
• EPA Substance Registry System: 5-(3-(2-chlorophenoxy)propyl)-8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole(1566528-07-1)

Safety Data

• Hazardous Substances Data: 1566528-07-1(Hazardous Substances Data)

Upstream product

• 95-57-8 2-monochlorophenol 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 1566528-31-1 C₂₃H₂₄ClFN₂O₃ 
• 50912-59-9 1-(3-bromo-propoxy)-2-chloro-benzene 
• 58038-66-7 2-carbethoxy-8-fluoro-2,3,4,5-tetrahydro-1H-pyrido<4,3-b>indole 

Relevant articles and documents

Novel Carboline Derivatives as Potent Antifungal Lead Compounds: Design, Synthesis, and Biological Evaluation

A series of novel antifungal carboline derivatives was designed and synthesized, which showed broad-spectrum antifungal activity. Particularly, compound C38 showed comparable in vitro antifungal activity to fluconazole without toxicity to human embryonic lung cells. It also exhibited good fungicidal activity against both fluconazole-sensitive and -resistant Candida albicans cells and had potent inhibition activity against Candida albicans biofilm formation and hyphal growth. Moreover, C38 showed good synergistic antifungal activity in combination with fluconazole (FLC) against FLC-resistant Candida species. Preliminary mechanism studies revealed that C38 might act by inhibiting the synthesis of fungal cell wall.