156698-95-2Relevant academic research and scientific papers
Asymmetric deprotonation-substitution of N-Pop-benzylamines using [RLi/(-)-sparteine]. Enantioselective sequential reactions and synthesis of N-heterocycles
Ona-Burgos, Pascual,Fernandez, Ignacio,Roces, Laura,Torre-Fernandez, Laura,Garcia-Granda, Santiago,Lopez-Ortiz, Fernando
supporting information; experimental part, p. 3195 - 3198 (2009/05/27)
(Chemical Equation Presented) Pop-directed asymmetric deprotonation of benzylic amines using [n-BuLi/(-)-sparteine] provides an efficient method for the synthesis of chiral NCα and NC α,α′ derivatives with total selectivity with respect to competing allylic and ortho lithiation. The method described herein offers a straightforward route of accessing chiral N-Pop-protected nitrogen heterocycles.
Unprecedented asymmetric induction through configurationally stable lithium N-(α-methylbenzyl)phosphinamides. A new entry to enantiomerically pure γ-aminophosphinic acids and esters
Fernandez, Ignacio,Ruiz Gomez, Gloria,Alfonso, Ignacio,Iglesias, Maria J.,Lopez Ortiz, Fernando
, p. 5408 - 5410 (2007/10/03)
The first examples of configurationally stable N-benzyl-N-phosphinoyl carbanions are described. Their applications to the synthesis of homochiral γ-aminophosphinic acids and esters via highly enantioselective dearomatising reactions are shown. The Royal S
Chiral phosphinamides: New catalysts for the asymmetric reduction of ketones by borane
Burns, Barry,King, N. Paul,Tye, Heather,Studley, John R.,Gamble, Mark,Wills, Martin
, p. 1027 - 1038 (2007/10/03)
We have identified a new class of catalysts for the asymmetric reduction of prochiral ketones by borane. Key to the architecture of effective catalysts is an N-P=O structural unit which may be part of a phosphinamide, phosphonamide or a related structure.
