156699-53-5Relevant academic research and scientific papers
H2O2-promoted reactions of aliphatic primary amines with 1,3-diketones for the synthesis of 1 H -pyrrol-3(2 H)-ones at ambient temperature in water
Sun, Xi,Li, Pinhua,Zhang, Xiuli,Wang, Lei
, p. 2126 - 2129 (2014/05/06)
A green organic reaction of aliphatic primary amines with 1,3-diketones promoted by 30% aqueous H2O2 has been developed. It provides an inexpensive, regioselective, and efficient approach to 1H-pyrrol-3(2H)-ones with high yields from the simple and readily available starting materials in one pot via multicomponent tandem cyclization reactions and C-C cleavage under very mild and environmentally friendly reaction conditions.
Cu(TFA)2-catalyzed oxidative tandem cyclization/1,2-alkyl migration of enamino amides for synthesis of pyrrolin-4-ones
Zhang, Zhi-Jing,Ren, Zhi-Hui,Wang, Yao-Yu,Guan, Zheng-Hui
, p. 4822 - 4825 (2013/10/08)
A novel Cu(TFA)2-catalyzed oxidative tandem cyclization/1,2- alkyl migration of readily available enamino amides for the synthesis of pyrrolin-4-ones has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the rapid synthesis of substituted pyrrolin-4-ones in high yields under mild conditions.
Efficient synthesis of highly substituted pyrrolin-4-ones via PIFA-mediated cyclization reactions of enaminones
Huang, Jie,Liang, Yongjiu,Pan, Wei,Yang, Yang,Dong, Dewen
, p. 5345 - 5348 (2008/09/17)
A convenient and efficient synthesis of highly substituted pyrrolin-4-ones is developed via the PIFA-mediated cyclization reactions of readily available enaminones, and a mechanism involving sequential cleavage of N - C bond, formation of new N - C bond, intramolecular addition reaction, and benzilic acid type rearrangement is proposed.
A NEW ROUTE TO HIGHLY SUBSTITUTED 1H-PYRROL-3(2H)-ONES
Adembri, Giorgio,Celli, Angela M.,Lampariello, Lucia R.,Scotton, Mirella,Sega, Alessandro
, p. 4023 - 4026 (2007/10/02)
Reaction of 3,4-diacetyl-3-hexen-2,5-dione, 1, with alkyl or aryl primary amines, 2a-g, led to highly substituted 1H-pyrrol-3(2H)-ones, 3a-g.The structure was established from a single crystal X-ray analysis of compound 3c.
