156706-65-9

Upstream product

• 117289-81-3 (2R,4S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-methylpentanal 
• 156659-93-7 (4R)-4-benzyl-3-((E)-(2S,6R,8S)-8-{[tert-butyl(dimethyl)silyl]oxy}-2,4,6-trimethylnon-4-enoyl)-1,3-oxazolidin-2-one 
• 156659-97-1 (E)-(2S,6R,8S)-8-Hydroxy-2,4,6-trimethyl-non-4-enoic acid 4-methoxy-benzyl ester 
• 156706-61-5 (S)-2-{(R)-2-[((S)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester 
• 156706-59-1 (S)-2-{(R)-2-[((S)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester 
• 156706-57-9 (S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester 
• 832677-11-9 (2E,4R,6S)-6-{[tert-butyl(dimethyl)silyl]oxy}-1-iodo-2,4-dimethylhept-2-ene 
• 156659-91-5 (2E,4R,6S)-6-{[tert-butyl(dimethyl)silyl]oxy}-2,4-dimethylhept-2-en-1-ol 
• 156659-89-1 (2R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-pentanenitrile 
• 156659-87-9 (2S,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-pentan-2-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 72345-23-4 (2S,4S)-pentane-2,4-diol 
• 119706-75-1 (R)-2-(tert-butoxycarbonylamino)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoic acid 
• 119706-71-7 N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine 

Downstream Products

• 127462-54-8 (S)-2-((R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid 
• 108675-63-4 geodiamolide A 
• 127462-55-9 (E)-(3S,6R,9S,12S,16R,18S)-6-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-3,7,9,12,14,16,18-heptamethyl-1-oxa-4,7,10-triaza-cyclooctadec-14-ene-2,5,8,11-tetraone 
• 1026931-00-9 (E)-(2S,6R,8S)-8-((S)-2-{(R)-2-[((S)-2-Amino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionylamino}-propionyloxy)-2,4,6-trimethyl-non-4-enoic acid 

Relevant academic research and scientific papers

An expeditious synthesis of geodiamolide a, an 18-membered cytotoxic depsipeptide from marine sponges

Geodiamolide A (1) has been efficiently synthesized from the polypropionate and tripeptide units using the Evans asymmetric alkylation, the Mitsunobu esterification, and the macrolactamization with diphenyl phosphorazidate (DPPA) as key steps. Efficient esterification between the complex polyketide and tripeptide units was also realized under high pressure conditions.

Efficient syntheses of geodiamolide A and jaspamide, cytotoxic and antifungal cyclic depsipeptides of marine sponge origin

Geodiamolide A (1a) and jaspamide (2) have been efficiently synthesized by use of the Evans asymmetric alkylation, the Mitsunobu esterification, and the DPPA macrolactamization as key steps.