119706-71-7

Upstream product

• 1026674-17-8 C₂₆H₄₇NO₅Si₂ 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 70642-86-3 N-(tert-butoxycarbonyl)-D-tyrosine 
• 119706-75-1 (R)-2-(tert-butoxycarbonylamino)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 156706-57-9 (S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester 
• 119706-72-8 3-bromo-O-tert-butyldimethylsilyl-N-methyl-N-t-BOC-D-tyrosine 
• 119724-72-0 (S)-2-((R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-methoxymethoxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid tert-butyl ester 
• 119724-73-1 (S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-(tert-butoxycarbonyl-methyl-amino)-propionylamino]-propionic acid tert-butyl ester 
• 119706-73-9 (S)-2-{(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methylamino-propionylamino}-propionic acid tert-butyl ester 
• 119724-74-2 (E)-(3S,6R,9S,12S,16R,18S)-6-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-benzyl]-3,7,9,12,14,16,18-heptamethyl-1-oxa-4,7,10-triaza-cyclooctadec-14-ene-2,5,8,11-tetraone 
• 119706-76-2 (S)-2-((R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid 
• 119706-74-0 (S)-2-{(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[((S)-2-tert-butoxycarbonylamino-propionyl)-methyl-amino]-propionylamino}-propionic acid tert-butyl ester 
• 119706-70-6 (S)-2-{(R)-2-[((S)-2-Amino-propionyl)-methyl-amino]-3-[3-bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid tert-butyl ester 
• 108675-64-5 (+)-geodiamolide B 
• 1026931-00-9 (E)-(2S,6R,8S)-8-((S)-2-{(R)-2-[((S)-2-Amino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionylamino}-propionyloxy)-2,4,6-trimethyl-non-4-enoic acid 
• 156706-65-9 (E)-(2S,6R,8S)-8-((S)-2-{(R)-2-[((S)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionylamino}-propionyloxy)-2,4,6-trimethyl-non-4-enoic acid 4-methoxy-benzyl ester 
• 156706-61-5 (S)-2-{(R)-2-[((S)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester 
• 156706-59-1 (S)-2-{(R)-2-[((S)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester 

Relevant academic research and scientific papers

Synthesis and conformational analysis of geodiamolide analogues

Starting with the ω-hydroxy and ω-amino acid derivatives 13 and 21, the two closely related geodiamolide analogs 32 and 35, respectively, were prepared. Compared to the natural cyclodepsipeptide geodiamolide (1), the macrocycles 32 and 35 have a smaller r

An expeditious synthesis of geodiamolide a, an 18-membered cytotoxic depsipeptide from marine sponges

Geodiamolide A (1) has been efficiently synthesized from the polypropionate and tripeptide units using the Evans asymmetric alkylation, the Mitsunobu esterification, and the macrolactamization with diphenyl phosphorazidate (DPPA) as key steps. Efficient esterification between the complex polyketide and tripeptide units was also realized under high pressure conditions.

Efficient syntheses of geodiamolide A and jaspamide, cytotoxic and antifungal cyclic depsipeptides of marine sponge origin

Geodiamolide A (1a) and jaspamide (2) have been efficiently synthesized by use of the Evans asymmetric alkylation, the Mitsunobu esterification, and the DPPA macrolactamization as key steps.