1567324-70-2

Basic information

• Product Name: 7-chloro-4-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline
• Synonyms: 7-chloro-4-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline
• CAS NO: 1567324-70-2
• Molecular Weight: 306.754
• Mol File: 1567324-70-2.mol

Chemical Properties

• CAS DataBase Reference: 7-chloro-4-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-4-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline(1567324-70-2)
• EPA Substance Registry System: 7-chloro-4-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline(1567324-70-2)

Safety Data

• Hazardous Substances Data: 1567324-70-2(Hazardous Substances Data)

Upstream product

• 86-98-6 4,7-dichloroquinoline 

Relevant articles and documents

Synthesis, Biological Evaluation and in Silico Computational Studies of 7-Chloro-4-(1 H-1,2,3-triazol-1-yl)quinoline Derivatives: Search for New Controlling Agents against Spodoptera frugiperda (Lepidoptera: Noctuidae) Larvae

The insecticidal and antifeedant activities of five 7-chloro-4-(1H-1,2,3-triazol-1-yl)quinoline derivatives were evaluated against the maize armyworm, Spodoptera frugiperda (J.E. Smith). These hybrids were prepared through a copper-catalyzed azide alkyne

New compounds hybrids 1H-1,2,3-triazole-quinoline against plasmodium falciparum

Malaria is one of the most prevalent parasitic diseases in the world. The global importance of this disease, current vector control limitations, and the absence of an effective vaccine make the use of therapeutic antimalarial drugs the main strategy to co

Quinoline-triazole half-sandwich iridium(iii) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies

Iridium(iii) half-sandwich complexes containing 7-chloroquinoline-1,2,3-triazole hybrid ligands were synthesised and their inhibitory activities evaluated against the Plasmodium falciparum malaria parasite. Supporting computational analysis revealed that metal coordination to the quinoline nitrogen occurs first, forming a kinetic product that, upon heating over time, forms a more stable cyclometallated thermodynamic product. Single crystal X-ray diffraction confirmed the proposed molecular structures of both isolated kinetic and thermodynamic products. Complexation with iridium significantly enhances the in vitro activity of selected ligands against the chloroquine-sensitive (NF54) Plasmodium falciparum strain, with selected complexes being over one hundred times more active than their respective ligands. No cross-resistance was observed in the chloroquine-resistant (K1) strain. No cytotoxicity was observed for selected complexes tested against the mammalian Chinese Hamster Ovarian (CHO) cell line. In addition, speed-of-action assays and β-haematin inhibition studies were performed. Through preliminary qualitative and quantitative cell-free experiments, it was found that the two most active neutral, cyclometallated complexes can act as transfer hydrogenation catalysts, by reducing β-nicotinamide adenine dinucleotide (NAD+) to NADH in the presence of a hydrogen source, sodium formate.

7-Chloroquinolinotriazoles: Synthesis by the azide-alkyne cycloaddition click chemistry, antimalarial activity, cytotoxicity and SAR studies

Twenty-seven 7-chloroquinolinotriazole derivatives with different substituents in the triazole moiety were synthesized via copper-catalyzed cycloaddition (CuAAC) click chemistry between 4-azido-7-chloroquinoline and several alkynes. All the synthetic compounds were evaluated for their in vitro activity against Plasmodium falciparum (W2) and cytotoxicity to Hep G2A16 cells. All the products disclosed low cytotoxicity (CC50 > 100 μM) and five of them have shown moderate antimalarial activity (IC50 from 9.6 to 40.9 μM). As chloroquine analogs it was expected that these compounds might inhibit the heme polymerization and SAR studies were performed aiming to explain their antimalarial profile. New structural variations can be designed on the basis of the results obtained.