1567334-50-2

Basic information

• Product Name: 2-chloro-4-[1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl]-pyridine
• CAS NO: 1567334-50-2
• Molecular Weight: 425.958
• Mol File: 1567334-50-2.mol

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-[1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl]-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-[1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl]-pyridine(1567334-50-2)
• EPA Substance Registry System: 2-chloro-4-[1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl]-pyridine(1567334-50-2)

Safety Data

• Hazardous Substances Data: 1567334-50-2(Hazardous Substances Data)

Upstream product

• 1567335-34-5 trifluoromethanesulfonic acid 2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-2H-pyrazol-3-yl ester 
• 458532-96-2 2-chloropyridine-4-boronic acid 
• 1567335-33-4 2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-2,4-dihydropyrazol-3-one 
• 57396-67-5 (2-methoxyphenyl)hydrazine hydrochloride 
• 1567335-32-3 3-oxo-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)thiopropionic acid S-phenyl ester 
• 1567335-31-2 benzotriazol-1-yl-(2,2,6,6-tetramethyltetrahydropyran-4-yl)methanone 
• 1197-66-6 2,2,6,6-tetramethyltetrahydropyran-4-one 

Relevant articles and documents

Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain

A novel series of pyrazolyltetrahydropyran N-type calcium channel blockers are described. Structural modifications of the series led to potent compounds in both a cell-based fluorescent calcium influx assay and a patch clamp electrophysiology assay. Representative compounds from the series were bioavailable and showed efficacy in the rat CFA and CCI models of inflammatory and neuropathic pain.

SUBSTITUTED PYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS

The present invention relates to compounds of Formula (I), wherein X1, X2, X3, X4, R1, R2, R3, and Q are as defined herein, useful as N-type calcium channel blockers.