1567688-04-3Relevant articles and documents
Synthesis of novel polyhydroxylated pyrrolidine-triazole/-isoxazole hybrid molecules
Lin, Cheng-Kun,Cheng, Li-Wei,Li, Huang-Yi,Yun, Wen-Yi,Cheng, Wei-Chieh
, p. 2100 - 2107 (2015)
A straightforward synthesis of novel, 2-heterocyclyl polyhydroxylated pyrrolidines is described. Stereocontrolled additions of nucleophiles to cyclic nitrones generated the corresponding 2,3-trans adducts, allowing the synthesis of the corresponding pyrrolidines via key intermediates bearing an alkyne and a nitrile oxide. Three hybrid systems, including a pyrrolidine with two isoxazoles and one triazole, are efficiently prepared via 1,3-dipolar cycloaddition. Biological testing of the product alkaloids showed that subtle structural variations have drastic effects on their inhibitory activities against glucosidases. This journal is