1567688-04-3Relevant articles and documents
Synthesis of novel polyhydroxylated pyrrolidine-triazole/-isoxazole hybrid molecules
Lin, Cheng-Kun,Cheng, Li-Wei,Li, Huang-Yi,Yun, Wen-Yi,Cheng, Wei-Chieh
, p. 2100 - 2107 (2015)
A straightforward synthesis of novel, 2-heterocyclyl polyhydroxylated pyrrolidines is described. Stereocontrolled additions of nucleophiles to cyclic nitrones generated the corresponding 2,3-trans adducts, allowing the synthesis of the corresponding pyrrolidines via key intermediates bearing an alkyne and a nitrile oxide. Three hybrid systems, including a pyrrolidine with two isoxazoles and one triazole, are efficiently prepared via 1,3-dipolar cycloaddition. Biological testing of the product alkaloids showed that subtle structural variations have drastic effects on their inhibitory activities against glucosidases. This journal is
GLYCOSIDASE INHIBITORS AND USES THEREOF
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Paragraph 00176, (2014/03/25)
The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.