15677-71-1Relevant academic research and scientific papers
Photo-organocatalytic synthesis of acetals from aldehydes
Nikitas, Nikolaos F.,Triandafillidi, Ierasia,Kokotos, Christoforos G.
supporting information, p. 669 - 674 (2019/02/14)
A mild and green photo-organocatalytic protocol for the highly efficient acetalization of aldehydes has been developed. Utilizing thioxanthenone as the photocatalyst and inexpensive household lamps as the light source, a variety of aromatic and aliphatic aldehydes have been converted into acyclic and cyclic acetals in high yields. The reaction mechanism was extensively studied.
Darmstoff Analogues. 3. Actions of Choline Esters of Acetal Phosphatidic Acids on Visceral Smooth Muscle
Marx, Michael H.,Wiley, Robert A.,Satchell, D. G.,Maguire, M. Helen
, p. 1319 - 1322 (2007/10/02)
A number of naturally occurring phospholipids, e.g. the acetal phosphatidic acid derivatives that comprise Darmstoff (1) and the phosphatidylcholine derivative platelet activating factor (PAF), cause contraction of certain visceral smooth muscles and cause platelet activation.Because the Darmstoff phosphatidic acids and PAF are structurally similar, it was of interest to compare the biological actions of choline esters of Darmstoff with those of PAF and of the parent Darmstoff phosphatidic acids.To this end, phosphocholine (3a), methyl>phosphocholine (3b), and methyl>phosphocholine (3c) were synthesized.Compounds 3a, 3b, 3c, and PAF caused dose-dependent relaxation of taenia coli strips.In contrast, the unesterified materials 1a and 1b, as well as lyso-PAF, caused contraction in taenia coli strips.Thus, the contractile effect of Darmstoff is reversed on esterification with choline.In preparations of whole trachea, both 1a and 3a had contractile effects similar to those of PAF.
