15678-07-6 Usage
Uses
Used in Oncology:
2,4,6-Tris(2-chloroethyl)-1,3,5-trioxane is used as a chemotherapeutic agent for the treatment of various types of cancer, including lymphomas, melanomas, and lung cancers. Its alkylating action causes DNA damage in cancer cells, disrupting their ability to divide and proliferate, ultimately leading to cell death.
Used in Combination Therapy:
2,4,6-Tris(2-chloroethyl)-1,3,5-trioxane is used as a component of combination chemotherapy regimens to enhance the overall effectiveness of cancer treatment. When used in conjunction with other chemotherapy drugs, TCT can improve the therapeutic outcomes by targeting different aspects of cancer cell biology and overcoming drug resistance.
Used in Cancer Research:
2,4,6-Tris(2-chloroethyl)-1,3,5-trioxane is also used as a research tool in the study of cancer biology and the development of novel anticancer therapies. Its mechanism of action and side effects provide valuable insights into the challenges and opportunities in cancer treatment, guiding the design of more effective and targeted therapies.
Despite its potential side effects, such as nausea, vomiting, and bone marrow suppression, 2,4,6-Tris(2-chloroethyl)-1,3,5-trioxane is generally well-tolerated by patients and remains an important agent in the fight against cancer. Its versatility in combination therapies and its role in advancing cancer research underscore its significance in the field of oncology.
Check Digit Verification of cas no
The CAS Registry Mumber 15678-07-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,6,7 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 15678-07:
(7*1)+(6*5)+(5*6)+(4*7)+(3*8)+(2*0)+(1*7)=126
126 % 10 = 6
So 15678-07-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H15Cl3O3/c10-4-1-7-13-8(2-5-11)15-9(14-7)3-6-12/h7-9H,1-6H2
15678-07-6Relevant academic research and scientific papers
MacLeod, Alexander J.,Rossiter, John T.
, p. 717 - 721 (1983)
A synthesis of 2-hydroxybut-3-enylglucosinolate (progoitrin) is described.Its properties and authentication of its biological activity are discussed.This is the first time that this particular glucosinolate has been isolated in pure form by synthesis.
H-type zeolite-catalyzed 1,4-addition of benzene derivatives to labile acrolein
Hayashi, Daijiro,Narisawa, Tomoyuki,Masui, Yoichi,Onaka, Makoto
supporting information, p. 460 - 471 (2016/04/26)
The 1,4-addition of benzene derivatives to acrolein is a straightforward way to synthesize 3-arylpropanals. A survey of acid catalysts for the 1,4-addition of methoxy-substituted benzenes to acrolein revealed that H-Beta and H-Y were the most suitable catalysts. We hypothesized three side-reactions: (1) the double 1,4-addition of acrolein to the starting benzene derivatives, (2) the Friedel-Crafts-type alkylation to the desired product, and (3) the self-polymerization of acrolein. The type (3) side-reaction was inhibited by two different methods which kept the concentration of acrolein low in the reaction mixture or in the zeolite pores. First, acrolein monomers were in situ generated through the gradual monomerization of an acrolein cyclic trimer. Second, using a reaction solvent lowered the acrolein concentration in the zeolite pores due to the competitive adsorption. We discovered that the content of monomeric acrolein in a solvent was closely related to the polarity of the solvent. Actually, both methods improved the yields for the 1,4-additions of 1,3-dimethoxybenzene to acrolein. Other electron-rich benzene derivatives, such as phenol and N, N-dimethylaniline, were also applicable to the 1,4-addition reactions.
