156787-63-2

Basic information

• Product Name: 2-phenyl-5-(trifluoromethyl)-1,3-benzothiazole
• Synonyms: 2-phenyl-5-(trifluoromethyl)-1,3-benzothiazole
• CAS NO: 156787-63-2
• Molecular Weight: 279.285
• Mol File: 156787-63-2.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2-phenyl-5-(trifluoromethyl)-1,3-benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-5-(trifluoromethyl)-1,3-benzothiazole(156787-63-2)
• EPA Substance Registry System: 2-phenyl-5-(trifluoromethyl)-1,3-benzothiazole(156787-63-2)

Safety Data

• Hazardous Substances Data: 156787-63-2(Hazardous Substances Data)

Upstream product

• 860-39-9 bis(2-nitro-4-trifluoromethylphenyl) disulfide 
• 100-46-9 benzylamine 
• 603-33-8 triphenylbismuthane 
• 23420-87-3 5-(trifluoromethyl)benzo[d]thiazole-2(3H)-thione 
• 100-52-7 benzaldehyde 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 19406-49-6 2-amino-4-trifluoromethylthiophenol 
• 100-51-6 benzyl alcohol 
• 103-82-2 phenylacetic acid 
• 591-50-4 iodobenzene 
• 119072-55-8 tert-butylisonitrile 
• 4274-38-8 2-amino-4-(trifluoromethyl)benzenethiol hydrochloride 
• 618-31-5 benzylidene dibromide 
• 108-86-1 bromobenzene 

Downstream Products

• 1097023-62-5 2-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)phenol 

Relevant articles and documents

Benzothiazole Synthesis: Mechanistic Investigation of an in Situ-Generated Photosensitizing Disulfide

The use of a visible light absorbing intermediate as a photosensitizer makes a chemical process simple and sustainable, obviating the need for the use of chemical additives. Herein, the formation of a photosensitizing disulfide in benzothiazole synthesis from 2-Aminothiophenol and aldehydes was proposed and confirmed through in-depth mechanistic studies. A series of photophysical and electrochemical investigations revealed that an in situ-generated disulfide photosensitizes molecular oxygen to generate the key oxidants, singlet oxygen and superoxide anion, for the dehydrogenation step.

Sulfur-Promoted Redox Cyclization of 2,2′-Dinitrodiphenyl Disulfides and Benzylamines

This study aims to develop green and sustainable advanced synthetic methods based on redox cyclization. Elemental sulfur is shown to promote the efficient synthesis of 2-substituted benzothiazoles from 2,2′-dinitrodiphenyl disulfides and benzylamines via redox cyclization in the absence of transition-metal catalysts and solvents. The 2-substituted benzothiazoles are obtained in good to excellent yields. This synthetic methodology is highly atom-economical and does not require any external oxidizing and/or reducing agents.

A fluorinated phenylbenzothiazole arrests the trypanosoma cruzi cell cycle and diminishes the infection of mammalian host cells

Chagas disease (CD) is a human infection caused by Trypanosoma cruzi. CD was traditionally endemic to the Americas; however, due to migration it has spread to countries where it is not endemic. The current chemotherapy to treat CD induces several side eff