156806-95-0

Upstream product

• 3943-97-3 methyl 4-hydroxycinnamate 
• 100798-34-3 methyl 3-[4-(methoxycarbonylmethoxy)phenyl]acrylate 
• 7400-08-0 p-Coumaric Acid 
• 731845-75-3 (E)-2-(4-(3-methoxy-3-oxoprop-1-en-1-yl)phenoxy)acetic acid 
• 540-51-2 2-bromoethanol 

Downstream Products

• 1012057-56-5 (E)-methyl 3-(4-(2-(tosyloxy)ethoxy)phenyl)acrylate 
• 1370730-17-8 C₁₈H₂₀O₇ 
• 1012057-57-6 (E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate 

Relevant academic research and scientific papers

Photosensitive compound and its photosensitive polymer

The invention is to provide a photosensitive compound suitable for a photoalignment method, a photosensitive polymer prepared from the compound, a photoaligning agent by using the compound and a liquid crystal alignment film prepared from the photoaligning agent. A photosensitive compound represented by formula (1): in formula (1), Y1 is a divalent group represented by formula (2-1) or (2-2); A1 is 1,4-phenylene or 1,4-cyclohexylene; Z1 is a single bond, —COO— or —OCO—; R1 and R2 are each independently hydrogen, fluorine or alkyl having 1 to 5 carbons; Q1 is independently a single bond or alkylene having 1 to 12 carbons; and n is 0 or 1. In formulas (2-1) and (2-2), W1 and W2 are each independently hydrogen, alkyl having 1 to 3 carbons or alkoxy having 1 to 3 carbons.

FORMULATION OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY

The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a β-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

TARTRATE SALTS OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY

The present invention relates to tartrate salts of quinazoline containing zinc-binding moiety based derivatives that are inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The tartrate salts may further act as HDAC inhibitors.

MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS

The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More specifically, the present invention relates to multi-functional small molecules wherein one functionality is capable of inhibiting histone deacetylases (HDAC) and the other functionality is capable of inhibiting a different cellular or molecular pathway involved in aberrant cell proliferation, differentiation or survival.

Novel Regioselective Ester Hydrolysis by Pig-Liver Esterase

Pig-liver esterase, which catalyzed the hydrolysis of substrates containing both saturated and αβ-unsaturated/cyclopropanecarboxylic esters (methyl and ethyl), was studied. An exclusive hydrolysis of the saturated esters was observed. Kinetic experiments revealed that the presence of deactivated carbonyl in the unsaturated/cyclopropanecarboxylic esters and their weaker bindings are both responsible for the observed specificity. The relative binding abilities of the substrates have been explained in light of Jones active-site model. The regioselectivity has been exploited in the synthesis of intermediates for the thromboxane synthetase inhibitor.