1568112-59-3Relevant academic research and scientific papers
Stereoselective synthesis of α-trifluoromethyl enones by AuI/CuI-co-catalyzed tandem 1,3-acyloxy migration/trifluoromethylation reaction of propargyl acetates
Ji, Yun-Long,Lin, Jin-Hong,Xiao, Ji-Chang,Gu, Yu-Cheng
, p. 7948 - 7954 (2014)
AuI/CuI-co-catalyzed tandem 1,3-acyloxy migration/trifluoromethylation reaction of propargyl esters to give α-trifluoromethyl enones in moderate yields and with excellent stereoselectivity is described. It is proposed that the reacti
Catalytic C-H α-trifluoromethylation of α,β-unsaturated carbonyl compounds
Fang, Zhongxue,Ning, Yongquan,Mi, Pengbing,Liao, Peiqiu,Bi, Xihe
supporting information, p. 1522 - 1525 (2014/04/03)
A copper(I)-catalyzed, regioselective C-H α-trifluoromethylation of α,β-unsaturated carbonyl compounds using Togni's reagent was developed. Diverse substrates, including enones as well as α,β- unsaturated esters, thioesters, and amides, stereospecifically afforded the corresponding (E)-α-trifluoromethylated products in moderate to high yields. Further, this method was applied to the C-H trifluoromethylation of drugs.
