156835-63-1

Basic information

• Product Name: D-PTAN
• Synonyms: DI-P-TOLUOYL-D-TARTARIC ANHYDRIDE;D-PTAN;O,O-Di-p-toluoyl-D-tartaric anhydride
• CAS NO: 156835-63-1
• Molecular Formula: C20H16O7
• Molecular Weight: 368.339
• Mol File: 156835-63-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 558.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• CAS DataBase Reference: D-PTAN(CAS DataBase Reference)
• NIST Chemistry Reference: D-PTAN(156835-63-1)
• EPA Substance Registry System: D-PTAN(156835-63-1)

Safety Data

• Hazardous Substances Data: 156835-63-1(Hazardous Substances Data)

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 87-69-4 tartaric acid 
• 133-37-9 DL-tartaric acid 
• 106-43-4 para-chlorotoluene 
• 87-69-4 L-Tartaric acid 
• 147-71-7 D-tartaric acid 
• 32634-68-7 (2S,3S)-di-4-toluoyltartaric acid 

Relevant articles and documents

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Method for preparing D/L-di(p-toluoyl)tartaric acid

The invention discloses a method for preparing D/L-di(p-toluoyl)tartaric acid, and relates to the technical field of production and processing of di(p-toluoyl)tartaric acid. The main reactions of D/L-di(p-toluoyl)tartaric acid are shown in the specification and include the esterification reaction, centrifuging/washing, hydrolysis, cooling crystallization, centrifuging, drying, recrystallization, centrifuging and drying. The method for preparing D/L-di(p-toluoyl)tartaric acid includes the steps that methylbenzene and tartaric acid are put into an esterification kettle, p-toluoyl chloride and thionyl chloride are dropwise added, and di(p-toluoyl)tartaric anhydride is generated; water is added to hydrolyze the di(p-toluoyl)tartaric anhydride, cooling crystallization, centrifuging and drying are carried out, and a crude product is obtained; a methylbenzene/acetone mixed solvent is added into the crude product, recrystallization and centrifuging are carried out, the solid-phase substances are dried, and the finished product is obtained, wherein distilling recycling of the methylbenzene and the methylbenzene/acetone mixed solvent is carried out in a reaction kettle, condensation is achieved through water cooling and frozen saline water freezing, the recycled methylbenzene solvent is stored through an intermediate tank, and only a small amount of disordered exhaust gas is exhausted.

Resolution of (+/-)-propranolol.

Two improvements in propranolol resolution were developed. Both the (+)- and (-)-di-(p-toluoyl)tartaric acids were used as the resolving agents. This procedure reduced the number of crystallizations needed to obtain a pure product. Furthermore, synthesis of the resolving agent was improved.