156838-66-3Relevant academic research and scientific papers
An improved williamson etherification of hindered alcohols promoted by 15-crown-5 and sodium hydride
Aspinall, Helen C.,Greeves, Nicholas,Lee, Wai-Man,McIver, Edward G.,Smith, Peter M.
, p. 4679 - 4682 (1997)
15-crown-5 greatly facilitates Williamson ether synthesis when sodium hydride base is used in THF solvent. This mild yet versatile procedure has been employed in the synthesis of new homochiral polyether ligands and bis-allylic ethers which are inaccessib
Stereoconvergent 'One-Pot' Tandem -Wittig-Anionic Oxy-cope Rearrangement of Acyclic Bis-Allylic Ethers in the Diastereoselective Synthesis of Substituted Tetrahydropyrans
Greeves, Nicholas,Vines, Katya Jane
, p. 1469 - 1470 (2007/10/02)
The unsaturated alcohols derived from a 'one-pot' tandem -Wittig-anionic oxy-Cope (AOC) rearrangement undergo a halocyclisation reaction with iodine in acetonitrile to give substituted tetrahydropyrans with a high degree of stereocontrol.
