156905-55-4

Basic information

• Product Name: 2-Benzenesulfonyl-N,N-diethyl-benzamide
• Synonyms: 2-Benzenesulfonyl-N,N-diethyl-benzamide
• CAS NO: 156905-55-4
• Molecular Weight: 317.409
• Mol File: 156905-55-4.mol

Chemical Properties

• CAS DataBase Reference: 2-Benzenesulfonyl-N,N-diethyl-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzenesulfonyl-N,N-diethyl-benzamide(156905-55-4)
• EPA Substance Registry System: 2-Benzenesulfonyl-N,N-diethyl-benzamide(156905-55-4)

Safety Data

• Hazardous Substances Data: 156905-55-4(Hazardous Substances Data)

Upstream product

• 1696-17-9 N,N-diethylbenzamide 
• 368-43-4 phenylsulfonyl fluoride 
• 455-16-3 p-toluenesulfonyl fluoride 

Downstream Products

• 126076-76-4 2-(phenylsulfonyl)benzaldehyde 

Relevant articles and documents

Directed Metalation of Diaryl Sulfone 2-Amides and 2-O-Carbamates. Regiospecific General Route to Thioxanthen-9-one 10,10-Dioxides via Anionic Friedel-Crafts and Remote Fries Rearrangement Equivalents

2-Carboxamido- and 2-O-carbamoyldiaryl sulfones 5, DMG = CONEt2 and DMG = OCONEt2, undergo LDA-mediated amide alternate ring migration and cyclization to thioxanthen-9-one 10,10-dioxides 6 and 8, respectively, in a general, synthetically useful reaction.

A practical in situ generation of the schwartz reagent. reduction of tertiary amides to aldehydes and hydrozirconation

A new, highly efficient in situ protocol (Cp2ZrCl2/LiAlH(OBu-t)3) is described for the generation of the Schwartz reagent which provides a convenient method for the amide to aldehyde reduction and the regioselective hydrozirconation-iodination of alkynes and alkenes. Highlighted are chemoselective reductions of benzamides derived by directed ortho metalation (DoM) chemistry, allowing the synthesis of valuable 1,2,3-substituted benzaldehydes. The single-step, three-component process proceeds in a very short reaction time, shows excellent functional group compatibility, and uses inexpensive and long-storage stable reducing reagents.