126076-76-4

Usage

Uses

Used in Organic Synthesis:
2-(Benzene sulfonyl)benzaldehyde is utilized as a reagent in organic synthesis for the preparation of a range of aromatic compounds. Its unique structure allows for the creation of diverse chemical entities, making it a valuable component in the synthesis process.
Used in Dye and Pigment Production:
In the dye and pigment industry, 2-(Benzene sulfonyl)benzaldehyde is employed for the production of various dyes and pigments. Its chemical properties contribute to the color and stability of these products, enhancing their performance in different applications.
Used in Pharmaceutical Industry:
2-(Benzene sulfonyl)benzaldehyde is also used in the pharmaceutical sector, where it plays a role in the development of new drugs. Its chemical structure offers potential for the creation of novel therapeutic agents.
Used in Cancer Treatment Research:
Due to its ability to induce apoptosis in cancer cells, 2-(Benzene sulfonyl)benzaldehyde is considered a potential candidate for cancer treatment research. Its potential as an anticancer agent is currently being explored, with the aim of developing new treatment options for various types of cancer.
Safety Considerations:

InChI:InChI=1/C13H10O3S/c14-10-11-6-4-5-9-13(11)17(15,16)12-7-2-1-3-8-12/h1-10H

Upstream product

• 13963-35-4 2-(phenylthio)toluene 
• 446-52-6 2-Fluorobenzaldehyde 
• 515-42-4 sodium phenylsulfonate 
• 1696-17-9 N,N-diethylbenzamide 
• 368-43-4 phenylsulfonyl fluoride 
• 156905-55-4 2-Benzenesulfonyl-N,N-diethyl-benzamide 
• 26260-02-6 2-iodobenzaldehyde 
• 873-55-2 sodium benzenesulfonate 
• 108-98-5 thiophenol 
• 89-98-5 2-chloro-benzaldehyde 
• 36943-39-2 2-(phenylthio)benzaldehyde 
• 127-63-9 diphenyl sulphone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 359015-61-5 2-[α-hydroxy-2-(phenylsulfonyl)benzyl]pyridine 
• 1161865-67-3 [3-(2-benzenesulfonylbenzyl)-5-fluoro-2-methylindol-1-yl]acetic acid methyl ester 
• 1312717-82-0 benzyl 2-(5-(2-chloropyridin-4-yl)-2-methyl-3-(2-(phenylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate 
• 1312717-95-5 ethyl 2-(2-methyl-4,5-diphenyl-3-(2-(phenylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate 
• 1415042-96-4 4-[2-(phenylsulfonyl)phenyl]but-3-en-2-one 
• 1415043-03-6 4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine 
• 1415043-30-9 Ethyl 2-(2,5-dimethyl-4-oxo-3-(2-(phenylsulfonyl)benzyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate 
• 1415043-31-0 {2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid 
• 1415043-61-6 {2,6,6-Trimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid 
• 1415043-75-2 {2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid 
• 1415043-76-3 Ethyl {2-methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate 
• 1415043-77-4 Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate 
• 1415043-78-5 {2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid 
• 1415043-79-6 Ethyl {5-(difluoromethyl)-2-methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate 

Relevant academic research and scientific papers

ARYL-SULFONAMIDE AND ARYL-SULFONE DERIVATIVES AS TRPML MODULATORS

The new arylsulfonamide and arylsulfone derivatives are modulators of TRPML and are useful in treating disorders related to TRPML activities and lysosome functions such as acid-related disorders and cancer.

Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists

Monocyclic and bicyclic ring systems were investigated as the "core" section of a series of diphenylsulphone-containing acetic acid CRTh2 receptor antagonists. A range of potencies were observed and single-digit nanomolar potencies were obtained in both the monocyclic and bicyclic cores. Residence times for the monocyclic compounds were very short. Some of the bicyclic cores displayed better residence times. A methyl group in the northern part of the core, between the head and tail was a necessary requirement for the beginnings of long residence times. Variations of the tail substitution maximised potencies and residence times.

A practical in situ generation of the schwartz reagent. reduction of tertiary amides to aldehydes and hydrozirconation

A new, highly efficient in situ protocol (Cp2ZrCl2/LiAlH(OBu-t)3) is described for the generation of the Schwartz reagent which provides a convenient method for the amide to aldehyde reduction and the regioselective hydrozirconation-iodination of alkynes and alkenes. Highlighted are chemoselective reductions of benzamides derived by directed ortho metalation (DoM) chemistry, allowing the synthesis of valuable 1,2,3-substituted benzaldehydes. The single-step, three-component process proceeds in a very short reaction time, shows excellent functional group compatibility, and uses inexpensive and long-storage stable reducing reagents.

Magnetically separable copper ferrite nanoparticles-catalyzed synthesis of diaryl, alkyl/aryl sulfones from arylsulfinic acid salts and organohalides/boronic acids

A recyclable, inexpensive, non-toxic and environmentally benign catalytic system comprised of magnetically separable copper ferrite (CuFe 2O4) nanoparticles has been developed for the synthesis of diaryl, alkyl/aryl sulfones. Arylsulfinic acid salts are coupled with various alkyl/aryl halides/boronic acids to afford the corresponding diaryl, alkyl/aryl sulfones in good to excellent yields under the identical catalytic system. A wide range of functional group tolerance, with facile recovery of the catalyst by application of an external magnetic field, and consistently high catalytic efficiency for five consecutive cycles render the protocol operationally attractive.

2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists

In this manuscript, the synthesis and biological activity of a series of pyrazole acetic acid derivatives as CRTh2 antagonists is presented. Biological evaluation in vitro revealed that the pyrazole core showed in several cases a different structure-activity relationship (SAR) to that of related indole acetic acid. A potent series of ortho-sulfonyl benzyl substituents was found, from which compounds 27 and 63 were advanced to in vivo profiling.

New CRTH2 Antagonists

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

New pyrazole derivatives having CRTh2 antagonistic behaviour

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

Schwartz Reagents: Methods of In Situ Generation and Use

Embodiments of the invention provide a method of using Schwartz Reagent, Cp2Zr(H)Cl, without accumulating or isolating it. Methods provide mixtures of Cp2ZrCl2, reductants that selectively reduce Cp2ZrCl2, and substrates. After reaction of Cp2ZrCl2 and the reductant, an intermediate reduction product is formed, apparently Schwartz Reagent. The in situ Schwartz Reagent then selectively reduces certain functional groups on the substrate. Substrates include tertiary amides, tertiary benzamides, aryl O-carbamates, and heteroaryl N-carbamates, which are reduced to aldehydes, benzaldehydes, aromatic alcohols, and heteroaromatics, respectively. Compared to prior methods, reagents are inexpensive and stable, reaction times are short, and reaction temperature in certain cases is conveniently room temperature. It has been estimated that using the in situ method described herein instead of synthesized or commercially obtained Schwartz Reagent provides a 50% reduction in cost.

CRTH2 MODULATORS

Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I