126076-76-4

Basic information

• Product Name: 2-(BENZENESULFONYL)BENZALDEHYDE
• Synonyms: 2-(Benzenesulphonyl)benzaldehyde
• CAS NO: 126076-76-4
• Molecular Formula: C₁₃H₁₀O₃S
• Molecular Weight: 246.2817
• Mol File: 126076-76-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 90-92
• Boiling Point: 448°C at 760 mmHg
• Flash Point: 288.3°C
• Appearance: /
• Density: 1.299g/cm³
• Vapor Pressure: 3.22E-08mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 2-(BENZENESULFONYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BENZENESULFONYL)BENZALDEHYDE(126076-76-4)
• EPA Substance Registry System: 2-(BENZENESULFONYL)BENZALDEHYDE(126076-76-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 126076-76-4(Hazardous Substances Data)

Usage

General Description

2-(Benzene sulfonyl)benzaldehyde is a chemical compound with the molecular formula C13H10O2S. It is an organic compound containing both aldehyde and sulfone functional groups. 2-(BENZENESULFONYL)BENZALDEHYDE is commonly used as a reagent in organic synthesis for the preparation of various aromatic compounds. It is also used in the production of dyes, pigments, and pharmaceuticals. Additionally, 2-(benzene sulfonyl)benzaldehyde is known for its ability to induce apoptosis in cancer cells, making it a potential candidate for cancer treatment research. 2-(BENZENESULFONYL)BENZALDEHYDE is considered to have moderate toxicity and should be handled with caution.

InChI:InChI=1/C13H10O3S/c14-10-11-6-4-5-9-13(11)17(15,16)12-7-2-1-3-8-12/h1-10H

Upstream product

• 873-55-2 sodium benzenesulfonate 
• 446-52-6 2-Fluorobenzaldehyde 
• 515-42-4 sodium phenylsulfonate 
• 1696-17-9 N,N-diethylbenzamide 
• 368-43-4 phenylsulfonyl fluoride 
• 156905-55-4 2-Benzenesulfonyl-N,N-diethyl-benzamide 
• 26260-02-6 2-iodobenzaldehyde 
• 108-98-5 thiophenol 
• 89-98-5 2-chloro-benzaldehyde 
• 36943-39-2 2-(phenylthio)benzaldehyde 
• 13963-35-4 2-(phenylthio)toluene 
• 127-63-9 diphenyl sulphone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1415042-96-4 4-[2-(phenylsulfonyl)phenyl]but-3-en-2-one 
• 126076-86-6 2-Benzenesulfonyl-benzaldehyde oxime 

Relevant articles and documents

ARYL-SULFONAMIDE AND ARYL-SULFONE DERIVATIVES AS TRPML MODULATORS

The new arylsulfonamide and arylsulfone derivatives are modulators of TRPML and are useful in treating disorders related to TRPML activities and lysosome functions such as acid-related disorders and cancer.

A practical in situ generation of the schwartz reagent. reduction of tertiary amides to aldehydes and hydrozirconation

A new, highly efficient in situ protocol (Cp2ZrCl2/LiAlH(OBu-t)3) is described for the generation of the Schwartz reagent which provides a convenient method for the amide to aldehyde reduction and the regioselective hydrozirconation-iodination of alkynes and alkenes. Highlighted are chemoselective reductions of benzamides derived by directed ortho metalation (DoM) chemistry, allowing the synthesis of valuable 1,2,3-substituted benzaldehydes. The single-step, three-component process proceeds in a very short reaction time, shows excellent functional group compatibility, and uses inexpensive and long-storage stable reducing reagents.

2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists

In this manuscript, the synthesis and biological activity of a series of pyrazole acetic acid derivatives as CRTh2 antagonists is presented. Biological evaluation in vitro revealed that the pyrazole core showed in several cases a different structure-activity relationship (SAR) to that of related indole acetic acid. A potent series of ortho-sulfonyl benzyl substituents was found, from which compounds 27 and 63 were advanced to in vivo profiling.