1569273-05-7Relevant articles and documents
Discovery of naphthyl-fused 5-membered lactams as a new class of M 1 positive allosteric modulators
Yang, Zhi-Qiang,Shu, Youheng,Ma, Lei,Wittmann, Marion,Ray, William J.,Seager, Matthew A.,Koeplinger, Kenneth A.,Thompson, Charles D.,Hartman, George D.,Bilodeau, Mark T.,Kuduk, Scott D.
, p. 604 - 608 (2014/06/09)
Selective activation of the M1 muscarinic receptor via positive allosteric modulation represents an original approach to treat the cognitive decline in patients with Alzheimer's disease. A series of naphthyl-fused 5-membered lactams were identified as a new class of M1 positive allosteric modulators and were found to possess good potency and in vivo efficacy.