1569280-32-5Relevant articles and documents
3-ARYLINDAZOLES AS SELECTIVE MEK4 INHIBITORS
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Paragraph 0027; 0421; 0426, (2021/01/22)
Disclosed are indazole compounds and derivatives thereof for use as modulators of the activity of mitogen-activated protein kinase 4 (MEK4). The disclosed compounds include 3-Arylindazoles which may be formulated in pharmaceutical composition for treating cell proliferative diseases and disorders associated with MEK4 activity, including cancer.
Microwave assisted solvent-free C-H amination by silica-supported manganese dioxide
Cao, Sufen,Duan, Wenhu
, p. 2390 - 2394 (2016/05/19)
An effective and convenient method has been developed for the preparation of 1-unsubstituted 1H-indazoles via C-H amination of N-acetylhydrazones in the presence of a catalytic amount of manganese dioxide under microwave irradiation. This new method featured easy operation and relatively short reaction-time.