1569303-95-2Relevant academic research and scientific papers
Diaryl and heteroaryl sulfides: Synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents
Yonova, Ivelina M.,Osborne, Charlotte A.,Morrissette, Naomi S.,Jarvo, Elizabeth R.
, p. 1947 - 1953 (2014)
A mild protocol for the synthesis of diaryl and heteroaryl sulfides is described. In a one-pot procedure, thiols are converted to sulfenyl chlorides and reacted with arylzinc reagents. This method tolerates functional groups including aryl fluorides and chlorides, ketones, as well as N-heterocycles including pyrimidines, imidazoles, tetrazoles, and oxadiazoles. Two compounds synthesized by this method exhibited selective activity against the MCF-7 breast cancer cell line in the micromolar range.
AROMATIC SULFIDE COMPOUNDS AND METHODS AND USE THEREOF
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Paragraph 0168; 0188, (2015/11/03)
Described herein, inter alia, are aromatic sulfide compositions and methods for treating or preventing cancer using the same.
