61686-49-5

Upstream product

• 15718-46-4 2,2'-dipyrimidyl disulfide 
• 131242-36-9 2-sulfanylpyrimidine 

Downstream Products

• 1569303-95-2 2-(3,4,5-trimethoxyphenylthio)pyrimidine 
• 1569303-94-1 3-(pyrimidin-2-ylthio)benzonitrile 
• 26547-29-5 2-[(4-methoxyphenyl)thio]pyrimidine 
• 14080-18-3 2-(pyrimidinylthio)benzene 
• 152527-25-8 5-(4-chlorophenylamino)-1,3-dimethyl-4-(2-pyrimidylthio)pyrazole 

Relevant academic research and scientific papers

AROMATIC SULFIDE COMPOUNDS AND METHODS AND USE THEREOF

Described herein, inter alia, are aromatic sulfide compositions and methods for treating or preventing cancer using the same.

Diaryl and heteroaryl sulfides: Synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents

A mild protocol for the synthesis of diaryl and heteroaryl sulfides is described. In a one-pot procedure, thiols are converted to sulfenyl chlorides and reacted with arylzinc reagents. This method tolerates functional groups including aryl fluorides and chlorides, ketones, as well as N-heterocycles including pyrimidines, imidazoles, tetrazoles, and oxadiazoles. Two compounds synthesized by this method exhibited selective activity against the MCF-7 breast cancer cell line in the micromolar range.

Heterocycle-substituted stable thioaminyl radicals: Isolation, ESR spectra, and magnetic properties

N-[(2-Benzothiazolyl)thio]- (1), N-[(2-benzoxazolyl)thio]- (2), and N-(2-pyrimidylthio)-2,4,6-trisubstituted-phenylaminyls (3) were generated by oxidation of the corresponding amines. Although 2 and were not sufficiently persistent to be isolated, I was very persistent and could be isolated as radical crystals. The ESR spectra of nondeuterated and partially deuterated 1-3 radicals were measured, and the spin density distributions were estimated from the hyperfine coupling constants. Ab initio molecular orbital calculations were made for 1 to discuss the spin density distribution in more detail. Single-crystal X-ray crystallographic analysis was performed for one radical. Magnetic properties were measured for isolated four radicals with a SQUID. Two radicals showed ferromagnetic interaction, and analyses of (x)T vs T plots with the one-dimensional regular Heisenberg model gave 2J/k(B) =5.8 and8.6K. The remaining two radicals showed antiferromagnetic interaction. Analyses of the (x)T vs T plots with the Curie-Weiss law or dimer model gave Θ = -1.4 K and 2J/k(B) = -1370K. The strong antiferromagnetic interaction could be explained in terms of the X-ray crystallographic results.

Phenyl, trihalomethyl or heteroaryl sulfoxides having a latent allyl group bound to sulfur as enzyme inhibitors

Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or Kcat type.