156944-40-0

Upstream product

• 156944-39-7 1-(2,4-difluorophenyl)-1,1-dimethoxy-2-propanol 
• 74-88-4 methyl iodide 
• 138311-20-3 2-(2,4-difluorophenyl)-2-methoxy-3-methyloxirane 
• 135206-83-6 2-bromo-1-(2,4-difluorophenyl)-1-propanone 
• 372-18-9 1,3-Difluorobenzene 

Downstream Products

• 156944-32-0 1-(2,4-difluorophenyl)-2-methoxy-1-propanone 

Relevant academic research and scientific papers

Stereoselective synthesis of antifungal agent threo-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1H-1,2,4-triazol-1-yl )-2-butanol (SM-8668)

The stereoselective synthesis of antifungal agent threo-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1H-1,2,4-triazol-1-yl )-2-butanol (SM-8668) is described. The key step is the selective synthesis of intermediate threo-2-(2,4-difluorophenyl)-2-(1-substituted ethyl)oxirane. threo-2-(2,4-difluorophenyl)-2-(1-methylthioethyl)oxirane was synthesized threo-selectively by the reaction of 1-(2,4-difluorophenyl)-2-methylthio-1-propanone with dimethyloxosulfonium methylide in a heterogeneous media consisting of a hydrophobic solvent and aqueous alkaline solution.